Synthroid and Pepcid complete drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Synthroid (levothyroxine sodium) and Pepcid complete (calcium carbonate; famotidine; magnesium hydroxide). Common drug interactions include chronic kidney disease among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Synthroid and Pepcid complete. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,202 Synthroid users. Check the latest studies of Synthroid.

What is Pepcid complete?

Pepcid complete has active ingredients of calcium carbonate; famotidine; magnesium hydroxide. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 2,884 Pepcid complete users. Check the latest studies of Pepcid complete.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

62 people who take Synthroid and Pepcid complete together, and have interactions are studied.

Synthroid and Pepcid complete drug interactions.

What are the common drug interactions of Synthroid and Pepcid Complete, by gender? *:

female:

Chronic kidney disease
Renal failure (kidney dysfunction)
Fatigue (feeling of tiredness)
Anxiety
Chest pain
Headache (pain in head)
Asthenia (weakness)
Dyspnoea (difficult or laboured respiration)
Electrocardiogram qt prolonged
Pain

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Intestinal perforation (complete penetration of the wall of the intestine)
Somnolence (a state of near-sleep, a strong desire for sleep)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Diabetic complication
Nephrogenic anaemia (anaemia due to kidney disease)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Death
Gastrointestinal disorder (functional problems of gastrointestinal tract)

What are the common drug interactions of Synthroid and Pepcid Complete, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Back pain
Blindness
Bone disorder
Bone fragmentation
Chest pain
Cutis laxa (connective tissue disorder in which the skin lacks elasticity and hangs in loose folds)
Deafness

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Depression
Gastric ulcer (stomach ulcer)
Renal injury (kidney injury)
Eating disorder
Injection site erythema (redness at injection site)
Injection site extravasation (flow of (blood or lymph) from injection site)
Injection site mass
Injection site pain

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Headache (pain in head)
Nephrogenic anaemia (anaemia due to kidney disease)
Tremor (trembling or shaking movements in one or more parts of your body)
Insomnia (sleeplessness)
Palpitations (feelings or sensations that your heart is pounding or racing)
Somnolence (a state of near-sleep, a strong desire for sleep)
Abscess (pus)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

What are the existing conditions these people have? *

Pain: 24 people, 38.71%
Stress And Anxiety: 14 people, 22.58%
High Blood Pressure: 11 people, 17.74%
Indigestion: 8 people, 12.90%
Sleep Disorder: 8 people, 12.90%
Depression: 7 people, 11.29%
Thyroid Diseases: 6 people, 9.68%
Asthma: 6 people, 9.68%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 6 people, 9.68%
Fever: 6 people, 9.68%

* Approximation only. Some reports may have incomplete information.

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