Tacrolimus and Accutane drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tacrolimus (tacrolimus) and Accutane (isotretinoin). Common drug interactions include colitis ulcerative among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Tacrolimus and Accutane. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Tacrolimus?

Tacrolimus has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 116,160 Tacrolimus users. Check the latest studies of Tacrolimus.

What is Accutane?

Accutane has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 35,221 Accutane users. Check the latest studies of Accutane.

On Aug, 02, 2026

11 people who take Tacrolimus and Accutane together, and have interactions are studied.

Tacrolimus and Accutane drug interactions.

What are the common drug interactions of Tacrolimus and Accutane, by gender? *:

female:

Colitis ulcerative (inflammation of colon with ulcer)
Inflammatory bowel disease
Depression
Dry skin
Abdominal pain
Alanine aminotransferase increased
Anal fissure
Arthralgia (joint pain)
Aspartate aminotransferase increased
Blood cholesterol increased

male:

Depression
Inflammatory bowel disease
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Irritable bowel syndrome
Lymphoma (cancer that begins in immune system cells)
Lymphoproliferative disorder (a medical condition in which the immune system makes too many white blood cells)
Neck injury
Oesophagitis (inflammation of oesophagus)

What are the common drug interactions of Tacrolimus and Accutane, by age (0-1 to 60+)? *:

0-1:

Depression
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Graft versus host disease in liver (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the liver)
Inflammatory bowel disease
Injury
Lymphadenitis (inflammation or enlargement of a lymph node)
Pallor
Pyrexia (fever)
Rash erythematous (redness of the skin)
Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)

2-9:

n/a

10-19:

Arthralgia (joint pain)
Back pain
Blood triglycerides increased
Colitis (inflammation of colon)
Colitis ulcerative (inflammation of colon with ulcer)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Depression
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

20-29:

Colitis ulcerative (inflammation of colon with ulcer)
Depression
Dry skin
Inflammatory bowel disease
Abdominal pain
Alanine aminotransferase increased
Anal fissure
Arthralgia (joint pain)
Aspartate aminotransferase increased
Blood cholesterol increased

30-39:

Acute graft versus host disease in intestine (acute complication in intestine following an allogeneic tissue/blood transplant)
Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Colitis ulcerative (inflammation of colon with ulcer)
Depression
Inflammatory bowel disease
Pain in extremity
Post transplant distal limb syndrome
Pruritus (severe itching of the skin)

40-49:

B-lymphocyte count decreased
Bk virus infection
Blood creatinine increased
Complications of transplanted kidney
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Injury
Kidney transplant rejection

50-59:

Colitis ulcerative (inflammation of colon with ulcer)
Inflammatory bowel disease
Aplasia pure red cell (type of anaemia affecting the precursors to red blood cells but not to white blood cells)
Blood bilirubin increased
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Death
Depression
Emotional distress
Hyperpyrexia (extremely high fever)
Injury

60+:

Colitis ulcerative (inflammation of colon with ulcer)
Depression
Platelet count decreased
Pyelonephritis (inflammation of kidney caused by bacteria)
Sepsis (a severe blood infection that can lead to organ failure and death)
Spinal compression fracture (fracture due to spinal compression on bone)
Inflammatory bowel disease
Injury
Cholecystitis (infection of gallbladder)
Cholecystitis acute (rapid infection of gallbladder)

What are the existing conditions these people have? *

Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 2 people, 18.18%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 9.09%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 1 person, 9.09%
Asthma: 1 person, 9.09%
Birth Control: 1 person, 9.09%
Dyslipidaemia (abnormal amount of lipids): 1 person, 9.09%
Enlarged Prostate: 1 person, 9.09%
Folate Deficiency (lack of folic acid): 1 person, 9.09%
Gastritis (inflammation of stomach): 1 person, 9.09%
Hidradenitis (chronic disease of a type of sweat gland): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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