Talwin and Ambien drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Talwin (pentazocine lactate) and Ambien (zolpidem tartrate). Common drug interactions include burning sensation among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Talwin and Ambien. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Talwin?

Talwin has active ingredients of pentazocine lactate. It is often used in pain. eHealthMe is studying from 893 Talwin users. Check the latest studies of Talwin.

What is Ambien?

Ambien has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 93,519 Ambien users. Check the latest studies of Ambien.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

64 people who take Talwin and Ambien together, and have interactions are studied.

What are the common drug interactions of Talwin and Ambien, by gender? *:

female:

Burning sensation
Cervical dysplasia (abnormal changes in the cells on the surface of the cervix)
Chronic kidney disease
Corneal deposits
Cystitis bacterial (inflammation of the wall of the bladder by bacteria escherichia coli)
Decreased interest
Deformity (disfigurement)
Dental caries
Depression
Drug dependence

male:

Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Alopecia (absence of hair from areas of the body)
Anaphylactic reaction (serious allergic reaction)
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Anxiety
Arthralgia (joint pain)
Back pain
Bipolar disorder (mood disorder)
Bone disorder

What are the common drug interactions of Talwin and Ambien, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hypersensitivity
Poor venous access
Colitis (inflammation of colon)
Impaired gastric emptying
Oesophagitis (inflammation of oesophagus)
Contusion (a type of hematoma of tissue in which capillaries)
Irritable bowel syndrome
Abdominal pain
Blood parathyroid hormone increased
Blood phosphorus increased

30-39:

Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)

40-49:

Cystitis bacterial (inflammation of the wall of the bladder by bacteria escherichia coli)
Decreased interest
Deformity (disfigurement)
Dental caries
Diarrhoea
Drug hypersensitivity
Dyshidrosis (skin condition in which blisters develop on the soles of your feet and/or the palms of hands)
Eating disorder
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Gingival disorder (gum disease)

50-59:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Abnormal dreams
Bladder discomfort
Blood urine present
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Colonoscopy
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Drug dependence
Drug hypersensitivity

60+:

Drug hypersensitivity
Hypersensitivity
Bone disorder
Cardiovascular disorder (heart diseases)
Cataract (clouding of the lens inside the eye)
Chondromalacia (anterior knee pain due to irritation of the cartilage on the under surface of the kneecap)
Colitis (inflammation of colon)
Compression fracture (fracture due to pressure caused by injury)
Contusion (a type of hematoma of tissue in which capillaries)
Depression

What are the existing conditions these people have? *

Stress And Anxiety: 24 people, 37.50%
High Blood Cholesterol: 23 people, 35.94%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 23 people, 35.94%
High Blood Pressure: 21 people, 32.81%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 20 people, 31.25%
Nausea (feeling of having an urge to vomit): 18 people, 28.12%
Multiple Allergies (allergy to multiple agents): 18 people, 28.12%
Fungal Infection: 18 people, 28.12%
Bipolar Disorder (mood disorder): 17 people, 26.56%
Constipation: 17 people, 26.56%

* Approximation only. Some reports may have incomplete information.

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