Tapentadol and Zolpidem drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tapentadol (tapentadol) and Zolpidem (zolpidem tartrate). Common drug interactions include stomatitis among females and alcohol interaction among males.

The phase IV clinical study analyzes what interactions people have when they take Tapentadol and Zolpidem. It is created by eHealthMe based on reports of 82 people who take the same drugs from the FDA, and is updated regularly.

What is Tapentadol?

Tapentadol has active ingredients of tapentadol. It is often used in chronic pain. eHealthMe is studying from 2,551 Tapentadol users. Check the latest studies of Tapentadol.

What is Zolpidem?

Zolpidem has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 92,695 Zolpidem users. Check the latest studies of Zolpidem.

On Jul, 13, 2026

82 people who take Tapentadol and Zolpidem together, and have interactions are studied.

Tapentadol and Zolpidem drug interactions.

What are the common drug interactions of Tapentadol and Zolpidem, by gender? *:

female:

Stomatitis (inflammation of mucous membrane of mouth)
Tendonitis (a condition that causes pain and swelling of tendons)
Thrombocytopenia (decrease of platelets in blood)
Tinnitus (a ringing in the ears)
Vision blurred
Vitamin d decreased
Wound
Activities of daily living impaired
Ascites (accumulation of fluid in the abdominal cavity)
Bedridden

male:

Alcohol interaction
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Neurogenic bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion)
Renal failure (kidney dysfunction)
Renal hypertension (high blood pressure caused by the kidneys hormonal response)
Fatigue (feeling of tiredness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Abdominal pain
Arthralgia (joint pain)

What are the common drug interactions of Tapentadol and Zolpidem, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Depression
Drug ineffective
Dysuria (painful or difficult urination)
Fatigue (feeling of tiredness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Suicidal ideation
Weight increased
Abnormal behaviour
Anxiety
Pain

20-29:

Intentional self-injury
Mydriasis (a dilation of the pupil)

30-39:

Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)

40-49:

Transferrin saturation increased
Completed suicide (act of taking one's own life)
Serum ferritin increased
Social problem

50-59:

Colitis (inflammation of colon)
Neutropenia (an abnormally low number of neutrophils)
Syncope (loss of consciousness with an inability to maintain postural tone)
Adverse drug reaction
Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Impaired gastric emptying
Renal failure (kidney dysfunction)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Urine osmolarity decreased

60+:

Alcohol interaction
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Malaise (a feeling of general discomfort or uneasiness)
Pain
Skin lesion
Weight decreased
Asthenia (weakness)
Confusional state
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Cancer Pain: 12 people, 14.63%
Pain: 8 people, 9.76%

* Approximation only. Some reports may have incomplete information.

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