Tarka and Clonazepam drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Tarka (trandolapril; verapamil hydrochloride) and Clonazepam (clonazepam). Common drug interactions include loss of consciousness among females and gastroenteritis viral among males.
The phase IV clinical study analyzes what interactions people have when they take Tarka and Clonazepam. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.
What is Tarka?
Tarka has active ingredients of trandolapril; verapamil hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 2,409 Tarka users. Check the latest studies of Tarka.
What is Clonazepam?
Clonazepam has active ingredients of clonazepam. It is often used in stress and anxiety. eHealthMe is studying from 146,270 Clonazepam users. Check the latest studies of Clonazepam.
26 people who take Tarka and Clonazepam together, and have interactions are studied.

What are the common drug interactions of Tarka and Clonazepam, by gender? *:
female:
- Loss of consciousness
- Hyperkalaemia (damage to or disease of the kidney)
- Pancreatitis (inflammation of pancreas)
- Renal failure acute (rapid kidney dysfunction)
- Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
- Pyrexia (fever)
- Suicide attempt
- Depression
- Bipolar disorder (mood disorder)
- Confusional state
male:
- Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
- Chest pain
- Type 2 diabetes mellitus
- Vomiting
- Confusional state
- Drug level decreased
- Drug level increased
- Ejaculation disorder
- Erosive oesophagitis (acid reflux disease can cause tissue damage in the oesophagus over time)
- Nausea (feeling of having an urge to vomit)
What are the common drug interactions of Tarka and Clonazepam, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Abnormal behaviour
- Aggression
- Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
- Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
- Depression
- Hallucination (an experience involving the perception of something not present)
- Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
- Mood swings (an extreme or rapid change in mood)
- Suicide attempt
40-49:
- Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
- Bipolar disorder (mood disorder)
- Loss of consciousness
- Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
- Suicide attempt
- Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
- Type 2 diabetes mellitus
50-59:
- Pancreatitis (inflammation of pancreas)
- Balance disorder
- Drug level decreased
- Drug level increased
- Ejaculation disorder
- Fall
- Loss of consciousness
- Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
- Normal pressure hydrocephalus (a neurological disorder in which there is too much cerebrospinal fluid in the ventricles of the brain)
- Pyrexia (fever)
60+:
- Hyperkalaemia (damage to or disease of the kidney)
- Renal failure acute (rapid kidney dysfunction)
- Adverse event
- Application site dryness
- Arthralgia (joint pain)
- Bradycardia (abnormally slow heart action)
- Cardiac failure congestive
- Cardiac murmur (an heart sound in valve abnormality)
- Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
- Chest pain
What are the existing conditions these people have? *
- Insomnia (sleeplessness): 9 people, 34.62%
- Diabetes: 9 people, 34.62%
- Depression: 7 people, 26.92%
- Hyperlipidaemia (presence of excess lipids in the blood): 6 people, 23.08%
- Respiratory Tract Infection: 4 people, 15.38%
- Quit Smoking: 4 people, 15.38%
- Pain: 4 people, 15.38%
- Dizziness: 3 people, 11.54%
- Throat Irritation: 2 people, 7.69%
- Enlarged Prostate: 2 people, 7.69%
* Approximation only. Some reports may have incomplete information.
Do you take Tarka and Clonazepam?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Tarka (2,409 reports)
- Clonazepam (146,270 reports)
Browse all drug interactions of Tarka and Clonazepam:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Tarka:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Clonazepam:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Tarka and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Clonazepam and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
- Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
- McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
- McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
- Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
- McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on trandolapril; verapamil hydrochloride and clonazepam (the active ingredients of Tarka and Clonazepam, respectively), and Tarka and Clonazepam (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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