Tecfidera and Amaryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tecfidera (dimethyl fumarate) and Amaryl (glimepiride). Common drug interactions include drug ineffective among females and gait disturbance among males.

The phase IV clinical study analyzes what interactions people have when they take Tecfidera and Amaryl. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Tecfidera?

Tecfidera has active ingredients of dimethyl fumarate. It is often used in multiple sclerosis. eHealthMe is studying from 129,627 Tecfidera users. Check the latest studies of Tecfidera.

What is Amaryl?

Amaryl has active ingredients of glimepiride. It is often used in diabetes. eHealthMe is studying from 32,259 Amaryl users. Check the latest studies of Amaryl.

On Aug, 03, 2026

40 people who take Tecfidera and Amaryl together, and have interactions are studied.

What are the common drug interactions of Tecfidera and Amaryl, by gender? *:

female:

Drug ineffective
Arthralgia (joint pain)
Alopecia (absence of hair from areas of the body)
Back pain
Balance disorder
Hot flush (sudden feelings of heat)
Urinary tract infection
Fall
Gait disturbance
Disturbance in attention

male:

Gait disturbance
Fall
Drug resistance (reduction in effectiveness of a drug)
Fatigue (feeling of tiredness)
Hemiparesis (weakness on one side of the body)
Hyperreflexia (overactive or over responsive reflexes)
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Mobility decreased (ability to move is reduced)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Platelet count increased

What are the common drug interactions of Tecfidera and Amaryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Flushing (the warm, red condition of human skin)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Breast cancer
Neuropathy peripheral (surface nerve damage)
Urinary tract infection

40-49:

Constipation
Pain in extremity
Arthralgia (joint pain)
Burning sensation
Drug ineffective
Feeling hot
Urinary tract infection

50-59:

Fall
Limb injury
Glioblastoma multiforme (most common and deadliest of malignant primary brain tumours in adults)
Chest pain
Contusion (a type of hematoma of tissue in which capillaries)
Cardiac failure congestive
Excessive granulation tissue (excessive collagen-rich tissue which forms at the site of an injury)
Fatigue (feeling of tiredness)
Head injury
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

60+:

Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Sleep disorder
Malaise (a feeling of general discomfort or uneasiness)
Blood glucose increased
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Abdominal distension
Asthma
Dyspepsia (indigestion)
Eructation (release of gas from the digestive tract)

What are the existing conditions these people have? *

Gait Disturbance: 5 people, 12.50%
Pain: 2 people, 5.00%
Laxative Supportive Care: 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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