Tecfidera and Jardiance drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tecfidera (dimethyl fumarate) and Jardiance (empagliflozin). Common drug interactions include stress among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Tecfidera and Jardiance. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Tecfidera?

Tecfidera has active ingredients of dimethyl fumarate. It is often used in multiple sclerosis. eHealthMe is studying from 129,627 Tecfidera users. Check the latest studies of Tecfidera.

What is Jardiance?

Jardiance has active ingredients of empagliflozin. It is often used in hyperglycemia. eHealthMe is studying from 44,459 Jardiance users. Check the latest studies of Jardiance.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

41 people who take Tecfidera and Jardiance together, and have interactions are studied.

Tecfidera and Jardiance drug interactions.

What are the common drug interactions of Tecfidera and Jardiance, by gender? *:

female:

Stress
Urinary tract infection
White blood cell count decreased
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood glucose decreased
Hypersensitivity
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Peripheral swelling
Red blood cell count decreased
Renal disorder (kidney disease)

male:

Diarrhoea
Abdominal discomfort
Intervertebral disc disorder (spinal disc disorder)
Intervertebral disc protrusion (spinal disc protrusion)
Speech disorder
Spinal osteoarthritis (joint cartilage loss in spine)
Spinal stenosis (narrowing of spinal column)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Weight decreased
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)

What are the common drug interactions of Tecfidera and Jardiance, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Diarrhoea
Faeces discoloured
Loss of consciousness
Weight decreased
Abdominal discomfort
Blood glucose decreased
Blood glucose increased

50-59:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hot flush (sudden feelings of heat)
Abdominal discomfort
Burning sensation
Pruritus (severe itching of the skin)
Anxiety
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Blood glucose increased
Constipation
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

60+:

Hypoaesthesia (reduced sense of touch or sensation)
Back disorder
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Optic nerve injury
Platelet count decreased
Stress
Type 2 diabetes mellitus
Urinary tract infection
White blood cell count decreased

What are the existing conditions these people have? *

Diabetes: 8 people, 19.51%
High Blood Cholesterol: 3 people, 7.32%
Gait Disturbance: 3 people, 7.32%
Chest Pain: 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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