Tekturna and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tekturna (aliskiren hemifumarate) and Actos (pioglitazone hydrochloride). Common drug interactions include ill-defined disorder among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Tekturna and Actos. It is created by eHealthMe based on reports of 71 people who take the same drugs from the FDA, and is updated regularly.

What is Tekturna?

Tekturna has active ingredients of aliskiren hemifumarate. It is often used in high blood pressure. eHealthMe is studying from 4,730 Tekturna users. Check the latest studies of Tekturna.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

On Jul, 18, 2026

71 people who take Tekturna and Actos together, and have interactions are studied.

What are the common drug interactions of Tekturna and Actos, by gender? *:

female:

Ill-defined disorder
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Lacunar infarction (a type of stroke)
Obesity (having too much body fat)
Oedema peripheral (superficial swelling)
Osteolysis (dissolution of bone)
Presyncope
Vision blurred
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Blood creatinine increased
Bone density decreased
Renal injury (kidney injury)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Cardiac failure congestive
Chest pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

What are the common drug interactions of Tekturna and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Renal failure (kidney dysfunction)
Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
Cardiac failure congestive
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Follicular thyroid cancer (cancer of the thyroid)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Papillary thyroid cancer
Post procedural hypothyroidism
Sepsis (a severe blood infection that can lead to organ failure and death)

40-49:

Emotional distress
Pain
Bone pain
Drug resistance (reduction in effectiveness of a drug)
Gait disturbance
Renal impairment (severely reduced kidney function)
Bone density decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
Chest injury

50-59:

Cardiac failure congestive
Chronic kidney disease
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Acute respiratory failure
Cardiac arrest
Cardiomyopathy (weakening of the heart muscle)
Chest pain
Infusion site haematoma (localized swelling filled with blood at infusion site)
Infusion site pain

60+:

Renal failure (kidney dysfunction)
Blood creatinine increased
Cardiomyopathy (weakening of the heart muscle)
Cardiovascular disorder (heart diseases)
Dizziness
Feeling cold
Glycosylated haemoglobin increased
Hypotension (abnormally low blood pressure)
Lacunar infarction (a type of stroke)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

What are the existing conditions these people have? *

High Blood Cholesterol: 15 people, 21.13%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 19.72%
Type 2 Diabetes: 7 people, 9.86%
Pain: 7 people, 9.86%
Insomnia (sleeplessness): 6 people, 8.45%
Infection: 6 people, 8.45%
Gastric Ulcer (stomach ulcer): 6 people, 8.45%
Skin Infection: 5 people, 7.04%
Fluid Retention (an abnormal accumulation of fluid in the blood): 5 people, 7.04%
Cough: 5 people, 7.04%

* Approximation only. Some reports may have incomplete information.

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