Temodar and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Temodar (temozolomide) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include hyperglycaemia among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Temodar and Benadryl. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Temodar?

Temodar has active ingredients of temozolomide. It is often used in glioblastoma multiforme. eHealthMe is studying from 6,683 Temodar users. Check the latest studies of Temodar.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

On Jul, 15, 2026

53 people who take Temodar and Benadryl together, and have interactions are studied.

What are the common drug interactions of Temodar and Benadryl, by gender? *:

female:

Hyperglycaemia (high blood sugar)
Thrombocytopenia (decrease of platelets in blood)
Rash
Constipation
Decreased appetite
Diarrhoea
Hypoaesthesia (reduced sense of touch or sensation)
Neutropenia (an abnormally low number of neutrophils)
Platelet count decreased
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

male:

Death
Diarrhoea
Abdominal pain
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Hemiplegia (paralysis of one side of the body)
Neoplasm progression (growth of tumour)
Pyrexia (fever)
Fall
Pain
Stomatitis (inflammation of mucous membrane of mouth)

What are the common drug interactions of Temodar and Benadryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abdominal distension
Ascites (accumulation of fluid in the abdominal cavity)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Immunodeficiency
Nausea (feeling of having an urge to vomit)
Pancreatic atrophy
Pyrexia (fever)
Staphylococcus test positive
Urinary tract infection

10-19:

n/a

20-29:

Abdominal pain lower
Appendicitis (inflammation of the appendix)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)

30-39:

Adverse event
Myalgia (muscle pain)
Rash
Urticaria (rash of round, red welts on the skin that itch intensely)
Abdominal discomfort
Dehydration (dryness resulting from the removal of water)
Drug hypersensitivity
Erythema multiforme (a type of hypersensitivity reaction)
Hypoaesthesia (reduced sense of touch or sensation)
Nausea (feeling of having an urge to vomit)

40-49:

Diarrhoea
Death
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Disease progression
Peripheral swelling
Thrombocytopenia (decrease of platelets in blood)
Abdominal pain
Cough
Mood altered (changes in mood)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)

50-59:

Acute monocytic leukaemia (a type of blood cancer)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Alanine aminotransferase increased
Alopecia (absence of hair from areas of the body)
Anxiety
Aspartate aminotransferase increased
Blood lactate dehydrogenase increased
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)

60+:

Hyperglycaemia (high blood sugar)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Dizziness
Fall
Nausea (feeling of having an urge to vomit)
Vomiting
Anaemia (lack of blood)
Aortic valve stenosis (narrowing of the aortic valve)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

What are the existing conditions these people have? *

Brain Neoplasm Malignant (brain cancer tumour): 18 people, 33.96%
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans): 5 people, 9.43%
Malignant Melanoma (skin cancer rises from melancytes): 4 people, 7.55%
Lung Neoplasm Malignant (cancer tumour of lung): 3 people, 5.66%
Anaplastic Astrocytoma (tumour of the glial (supportive) tissue of the brain): 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

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