Tenoretic 100 and Glucophage drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tenoretic 100 (atenolol; chlorthalidone) and Glucophage (metformin hydrochloride). Common drug interactions include proctalgia among females and cardiac disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Tenoretic 100 and Glucophage. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Tenoretic 100?

Tenoretic 100 has active ingredients of atenolol; chlorthalidone. It is often used in high blood pressure. eHealthMe is studying from 935 Tenoretic 100 users. Check the latest studies of Tenoretic 100.

What is Glucophage?

Glucophage has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 60,851 Glucophage users. Check the latest studies of Glucophage.



On Jul, 13, 2026

28 people who take Tenoretic 100 and Glucophage together, and have interactions are studied.

Tenoretic 100 and Glucophage drug interactions.

What are the common drug interactions of Tenoretic 100 and Glucophage, by gender? *:

female:

  1. Proctalgia (pain in the rectum)
  2. Rectal haemorrhage (bleeding from anus)
  3. Vaginal haemorrhage (vaginal bleeding)
  4. Abdominal pain
  5. Gastric disorder (disease of stomach)
  6. Gastric perforation (hole in stomach)
  7. Hypokalaemia (low potassium)
  8. Arrhythmia (irregular heartbeat)
  9. Cardiac arrest
  10. Diarrhoea

male:

  1. Cardiac disorder
  2. Blood cholesterol increased
  3. Pleural effusion (water on the lungs)
  4. Post procedural complication
  5. Pulmonary congestion (congestion in the lungs)
  6. Surgery
  7. Cardiac failure congestive
  8. Chest pain
  9. Gangrene (body tissue dies)
  10. Joint stiffness

What are the common drug interactions of Tenoretic 100 and Glucophage, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Chest pain
  2. Dyspnoea (difficult or laboured respiration)
  3. Fluid retention (an abnormal accumulation of fluid in the blood)
  4. Squamous cell carcinoma of the cervix (cervix cancer of a kind of epithelial cell)
  5. Weight increased

40-49:

n/a

50-59:

  1. Arrhythmia (irregular heartbeat)
  2. Cardiac arrest
  3. Hypokalaemia (low potassium)
  4. Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
  5. Multi-organ failure (multisystem organ failure)
  6. Pancreatitis acute (sudden inflammation of pancreas)
  7. Renal failure acute (rapid kidney dysfunction)
  8. Septic shock (shock due to blood infection)
  9. Cardiac disorder
  10. Cardiac failure congestive

60+:

  1. Abdominal pain
  2. Gastric disorder (disease of stomach)
  3. Chest pain
  4. Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
  5. Dehydration (dryness resulting from the removal of water)
  6. Dysphagia (a condition in which swallowing is difficult or painful)
  7. Dysphonia (speech disorder attributable to a disorder of phonation)
  8. Gangrene (body tissue dies)
  9. Joint stiffness
  10. Muscle weakness (a lack of muscle strength)

What are the existing conditions these people have? *

  1. Pain: 9 people, 32.14%
  2. Back Pain: 4 people, 14.29%
  3. Type 2 Diabetes: 3 people, 10.71%
  4. Gastric Ulcer (stomach ulcer): 2 people, 7.14%
  5. Fungal Infection: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Tenoretic 100 and Glucophage?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Tenoretic 100 and Glucophage:

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Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tenoretic 100:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Glucophage:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Tenoretic 100 and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Glucophage and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on atenolol; chlorthalidone and metformin hydrochloride (the active ingredients of Tenoretic 100 and Glucophage, respectively), and Tenoretic 100 and Glucophage (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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