Tessalon and Tracleer drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tessalon (benzonatate) and Tracleer (bosentan). Common drug interactions include pruritus among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Tessalon and Tracleer. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Tessalon?

Tessalon has active ingredients of benzonatate. It is often used in cough. eHealthMe is studying from 6,493 Tessalon users. Check the latest studies of Tessalon.

What is Tracleer?

Tracleer has active ingredients of bosentan. It is often used in primary pulmonary hypertension. eHealthMe is studying from 55,125 Tracleer users. Check the latest studies of Tracleer.

On Jul, 26, 2026

52 people who take Tessalon and Tracleer together, and have interactions are studied.

Tessalon and Tracleer drug interactions.

What are the common drug interactions of Tessalon and Tracleer, by gender? *:

female:

Pruritus (severe itching of the skin)
Sinus disorder (disease of sinus)
Wound infection
Acidosis (build-up of carbon dioxide in the blood)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Ascites (accumulation of fluid in the abdominal cavity)
Blood alkaline phosphatase increased
Blood bicarbonate decreased
Blood carbon dioxide increased

male:

Dyspnoea (difficult or laboured respiration)
Dysphagia (a condition in which swallowing is difficult or painful)
Eye oedema (swelling or thickening of the macula, the area of the retina responsible for central vision)
Fatigue (feeling of tiredness)
Heart transplant
Hyperlipidaemia (presence of excess lipids in the blood)
Joint swelling
Oedema (fluid collection in tissue)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pleural effusion (water on the lungs)

What are the common drug interactions of Tessalon and Tracleer, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Dyspnoea (difficult or laboured respiration)
Syncope (loss of consciousness with an inability to maintain postural tone)

40-49:

Nausea (feeling of having an urge to vomit)
Headache (pain in head)
Oral mucosal blistering (mouth ulcer)
Pyrexia (fever)
Hepatomegaly (abnormal enlargement of the liver)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Chest pain
Dry mouth
Dyspnoea exertional (breathlessness or shortness of breath)

50-59:

Heart rate increased
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Rhinorrhoea (watery mucus discharge from the nose)
Skin ulcer
Acute respiratory failure
Alanine aminotransferase increased
Aspartate aminotransferase increased
Bilirubin conjugated increased
Blood creatine phosphokinase increased
Cardiac arrest

60+:

Dyspnoea (difficult or laboured respiration)
Oedema peripheral (superficial swelling)
Localised oedema (fluid retention in a particular part of the body)
Rash
Respiratory failure (inadequate gas exchange by the respiratory system)
Headache (pain in head)
Heart rate increased
Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
Anaemia (lack of blood)
Aspartate aminotransferase increased

What are the existing conditions these people have? *

Pulmonary Hypertension (increase in blood pressure in the lung artery): 16 people, 30.77%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 9.62%
Nausea (feeling of having an urge to vomit): 4 people, 7.69%
Pulmonary Hypertension Secondary (increase in blood pressure in the lung artery): 3 people, 5.77%
Pulmonary Hypertension Primary (increase in blood pressure in the lung artery with no cause): 3 people, 5.77%
Oedema (fluid collection in tissue): 3 people, 5.77%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

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