Theo-dur and Zyprexa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Theo-dur (theophylline) and Zyprexa (olanzapine). Common drug interactions include white blood cell count increased among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Theo-dur and Zyprexa. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Theo-dur?

Theo-dur has active ingredients of theophylline. It is often used in asthma. eHealthMe is studying from 4,451 Theo-dur users. Check the latest studies of Theo-dur.

What is Zyprexa?

Zyprexa has active ingredients of olanzapine. It is often used in bipolar disorder. eHealthMe is studying from 64,724 Zyprexa users. Check the latest studies of Zyprexa.



On Jul, 11, 2026

31 people who take Theo-dur and Zyprexa together, and have interactions are studied.

Theo-dur and Zyprexa drug interactions.

What are the common drug interactions of Theo-Dur and Zyprexa, by gender? *:

female:

  1. White blood cell count increased
  2. Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
  3. Hypokalaemia (low potassium)
  4. Primary hyperaldosteronism (too much aldosterone is produced by the adrenal glands)
  5. Adrenal cortex atrophy (partial or complete wasting away of a adrenal cortex)
  6. Adverse drug reaction
  7. Anaemia (lack of blood)
  8. Ascites (accumulation of fluid in the abdominal cavity)
  9. Atelectasis (partial or complete collapse of the lung)
  10. Blood alkaline phosphatase increased

male:

  1. Pneumonia
  2. Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
  3. Dyspnoea (difficult or laboured respiration)
  4. Effusion (an escape of fluid into a body cavity)
  5. Feeding disorder (when children refuse to eat certain food groups)
  6. Injury asphyxiation
  7. Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
  8. Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
  9. Peripheral swelling
  10. Soliloquy

What are the common drug interactions of Theo-Dur and Zyprexa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Adverse drug reaction
  2. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  3. Drug exposure during pregnancy
  4. Gestational diabetes (diabetes in pregnancy)
  5. Type 2 diabetes mellitus

30-39:

  1. Suicide attempt

40-49:

  1. Blood glucose decreased
  2. Blood pressure systolic increased
  3. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  4. Chest pain
  5. Cholecystitis (infection of gallbladder)
  6. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  7. Cyst (a closed sac)
  8. Decreased appetite
  9. Diarrhoea
  10. Dizziness

50-59:

  1. Fatigue (feeling of tiredness)
  2. Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
  3. Chest pain
  4. Dental caries
  5. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  6. Dysfunctional uterine bleeding
  7. Ear pain
  8. Hyperglycaemia (high blood sugar)
  9. Hypertension (high blood pressure)
  10. Local swelling (swelling at the site of some application of substance or injury)

60+:

  1. Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
  2. Pneumonia
  3. Dementia (madness)
  4. Hospitalisation
  5. Hypoxia (low oxygen in tissues)
  6. Insomnia (sleeplessness)
  7. Muscle rigidity (muscle stiffness)
  8. Overdose
  9. Pyrexia (fever)
  10. Disseminated intravascular coagulation (systemic activation of blood coagulation)

What are the existing conditions these people have? *

  1. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 13 people, 41.94%
  2. Insomnia (sleeplessness): 6 people, 19.35%
  3. Depression: 5 people, 16.13%
  4. Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 4 people, 12.90%
  5. Psychiatric Symptom: 3 people, 9.68%
  6. Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 9.68%
  7. Stress And Anxiety: 2 people, 6.45%
  8. Schizoaffective Disorder (a mental disorder characterized by disordered thought): 2 people, 6.45%
  9. Headache (pain in head): 2 people, 6.45%
  10. Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Theo-dur and Zyprexa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Theo-dur:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Zyprexa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Theo-dur and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zyprexa and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on theophylline and olanzapine (the active ingredients of Theo-dur and Zyprexa, respectively), and Theo-dur and Zyprexa (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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