Theophyl and Cefobid drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Theophyl (theophylline) and Cefobid (cefoperazone sodium). Common drug interactions include c-reactive protein increased among females and cardio-respiratory arrest among males.
The phase IV clinical study analyzes what interactions people have when they take Theophyl and Cefobid. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.
What is Theophyl?
Theophyl has active ingredients of theophylline. eHealthMe is studying from 19,174 Theophyl users. Check the latest studies of Theophyl.
What is Cefobid?
Cefobid has active ingredients of cefoperazone sodium. eHealthMe is studying from 1,317 Cefobid users. Check the latest studies of Cefobid.
14 people who take Theophyl and Cefobid together, and have interactions are studied.

What are the common drug interactions of Theophyl and Cefobid, by gender? *:
female:
- C-reactive protein increased
- Colitis pseudomembranous (antibiotic-associated diarrhoea)
male:
- Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
- Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
- Asthma
- Blood immunoglobulin e increased
- Blood osmolarity increased
- Cardiac failure acute
- Cardiac tamponade (fluid accumulates in heart covering)
- Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
- Diabetes insipidus (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function)
- Drug effect decreased
What are the common drug interactions of Theophyl and Cefobid, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Haematemesis (vomiting of blood)
- Respiratory distress (difficulty in breathing)
40-49:
n/a
50-59:
- Abnormal behaviour
- Restlessness (not able to rest)
60+:
- Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
- Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
- C-reactive protein increased
- Cardiac failure acute
- Cardiac tamponade (fluid accumulates in heart covering)
- Colitis pseudomembranous (antibiotic-associated diarrhoea)
- Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
- Drug effect decreased
- Drug eruption (adverse drug reaction of the skin)
- Drug maladministration
* Approximation only. Some reports may have incomplete information.
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Theophyl and Cefobid:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Theophyl:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Cefobid:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Theophyl and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Cefobid and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Korang-Yeboah M, Rahman Z, Shah D, Mohammad A, Wu S, Siddiqui A, Khan MA, "Impact of formulation and process variables on solid-state stability of theophylline in controlled release formulations", International journal of pharmaceutics, 2016 Feb .
- Dhaval MK, "Impact of formulation and process variables on solid-state stability of theophylline in controlled release formulations", International Journal of Pharmaceutics, 2016 Jan .
- Korang-Yeboah M, Rahman Z, Shah D, Mohammad A, Wu S, Siddiqui A, Khan MA, "Impact of formulation and process variables on solid-state stability of theophylline in controlled release formulations", International journal of pharmaceutics, 2016 Feb .
- Dhaval MK, "Impact of formulation and process variables on solid-state stability of theophylline in controlled release formulations", International Journal of Pharmaceutics, 2016 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on theophylline and cefoperazone sodium (the active ingredients of Theophyl and Cefobid, respectively), and Theophyl and Cefobid (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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