Theophyl and Zyflo drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Theophyl (theophylline) and Zyflo (zileuton). Common drug interactions include dysstasia among females and blood alkaline phosphatase nos increased among males.

The phase IV clinical study analyzes what interactions people have when they take Theophyl and Zyflo. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Theophyl?

Theophyl has active ingredients of theophylline. eHealthMe is studying from 19,174 Theophyl users. Check the latest studies of Theophyl.

What is Zyflo?

Zyflo has active ingredients of zileuton. eHealthMe is studying from 1,004 Zyflo users. Check the latest studies of Zyflo.

On Jul, 16, 2026

73 people who take Theophyl and Zyflo together, and have interactions are studied.

What are the common drug interactions of Theophyl and Zyflo, by gender? *:

female:

Dysstasia (difficulty in standing)
Emotional distress
Epistaxis (bleed from the nose)
Eye pain
Gamma-glutamyltransferase increased
Hyperacusis (disorder in loudness perception)
Hypersensitivity
Ill-defined disorder
Infusion site erythema (reddening of the skin at infusion site)
Lower respiratory tract infection

male:

Blood alkaline phosphatase nos increased
Dyspnoea (difficult or laboured respiration)
Abdominal pain upper
Aldolase increased
Asthma
Back disorder
Blood creatine phosphokinase increased
Blood immunoglobulin e increased
Blood pressure fluctuation
Cardiac failure

What are the common drug interactions of Theophyl and Zyflo, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Dyspnoea (difficult or laboured respiration)
Oropharyngeal pain
Anaphylactic reaction (serious allergic reaction)
Influenza like illness

40-49:

Blood alkaline phosphatase nos increased
Blood bilirubin increased
Cardiac failure
Death
Eye pain
Facial pain
Gamma-glutamyltransferase increased
Hyperbilirubinaemia (excess of bilirubin in the blood)
Influenza like illness
Infusion site erythema (reddening of the skin at infusion site)

50-59:

Myalgia (muscle pain)
Pain
Arthralgia (joint pain)
Asthenia (weakness)
Aldolase increased
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asthma
Blood alkaline phosphatase nos increased
Blood creatine phosphokinase increased
Blood immunoglobulin e increased

60+:

Asthma
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Influenza
Infusion site erythema (reddening of the skin at infusion site)
Infusion site swelling
Lymphadenopathy (disease or enlargement of lymph nodes)
Malaise (a feeling of general discomfort or uneasiness)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Asthma: 32 people, 43.84%
Fibromyalgia (a long-term condition which causes pain all over the body): 9 people, 12.33%
Migraine (headache): 7 people, 9.59%
Hypersensitivity: 7 people, 9.59%
Allergic Rhinitis: 7 people, 9.59%
Seasonal Allergy (allergic condition due to certain season): 6 people, 8.22%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 5 people, 6.85%

* Approximation only. Some reports may have incomplete information.

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