Timoptic and Zestril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Timoptic (timolol maleate) and Zestril (lisinopril). Common drug interactions include aspartate aminotransferase increased among females and vomiting among males.

The phase IV clinical study analyzes what interactions people have when they take Timoptic and Zestril. It is created by eHealthMe based on reports of 82 people who take the same drugs from the FDA, and is updated regularly.

What is Timoptic?

Timoptic has active ingredients of timolol maleate. It is often used in glaucoma. eHealthMe is studying from 4,247 Timoptic users. Check the latest studies of Timoptic.

What is Zestril?

Zestril has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 22,273 Zestril users. Check the latest studies of Zestril.

On Jul, 04, 2026

82 people who take Timoptic and Zestril together, and have interactions are studied.

What are the common drug interactions of Timoptic and Zestril, by gender? *:

female:

Aspartate aminotransferase increased
Blood bilirubin increased
Blood lactate dehydrogenase increased
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Dizziness
Eye irritation
Hepatic failure (liver failure)
Hepatitis (inflammation of the liver)
Malaise (a feeling of general discomfort or uneasiness)

male:

Vomiting
Anaemia (lack of blood)
Dyspnoea (difficult or laboured respiration)
Hypotension (abnormally low blood pressure)
Jaundice cholestatic
Bile duct stone
Cd4 lymphocytes decreased
Pancreatitis chronic (chronic inflammation of pancreas)
Fatigue (feeling of tiredness)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

What are the common drug interactions of Timoptic and Zestril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blindness
Blood glucose decreased
Blood glucose increased
Diabetes mellitus inadequate control
Diplopia (double vision)
Headache (pain in head)
Intraocular pressure increased
Neovascularisation (development of tiny, abnormal, leaky blood vessels inside the eye)
Retinopathy diabetic (acute damage to the retina of the eye due to diabetes)
Vision blurred

40-49:

Fatigue (feeling of tiredness)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood bilirubin increased
Blood lactate dehydrogenase increased
Hepatic failure (liver failure)
Hepatitis (inflammation of the liver)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)

50-59:

Spinal osteoarthritis (joint cartilage loss in spine)
Vomiting
Abdominal pain lower
Abscess intestinal (collections of pus-intestinal)
Adrenal disorder
Anaemia (lack of blood)
Anxiety
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthralgia (joint pain)
Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)

60+:

Anaemia (lack of blood)
Inappropriate antidiuretic hormone secretion
Bile duct stone
Cd4 lymphocytes decreased
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Hypotension (abnormally low blood pressure)
Pain
Pancreatitis chronic (chronic inflammation of pancreas)
Platelet count decreased

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 8.54%
Psoriasis (immune-mediated disease that affects the skin): 5 people, 6.10%

* Approximation only. Some reports may have incomplete information.

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