Tizanidine hydrochloride and Concerta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tizanidine hydrochloride (tizanidine hydrochloride) and Concerta (methylphenidate hydrochloride). Common drug interactions include sleep-related eating disorder among females and bone pain among males.

The phase IV clinical study analyzes what interactions people have when they take Tizanidine hydrochloride and Concerta. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Tizanidine hydrochloride?

Tizanidine hydrochloride has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 7,453 Tizanidine hydrochloride users. Check the latest studies of Tizanidine hydrochloride.

What is Concerta?

Concerta has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 25,040 Concerta users. Check the latest studies of Concerta.

On Jul, 31, 2026

26 people who take Tizanidine hydrochloride and Concerta together, and have interactions are studied.

Tizanidine hydrochloride and Concerta drug interactions.

What are the common drug interactions of Tizanidine Hydrochloride and Concerta, by gender? *:

female:

Sleep-related eating disorder (abnormal eating patterns during the night)
Somnambulism (sleep walking)
Weight decreased
Fall
Abnormal sleep-related event
Head injury
Urinary tract infection
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)

male:

Bone pain
Fatigue (feeling of tiredness)
Injection site pain
Injection site reaction
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pyrexia (fever)

What are the common drug interactions of Tizanidine Hydrochloride and Concerta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Intervertebral disc degeneration (spinal disc degeneration)

40-49:

Concussion (short loss of normal brain function in response to a head injury)
Drug ineffective
Dry mouth
Headache (pain in head)
Hypertension (high blood pressure)
Migraine (headache)
Nephrolithiasis (calculi in the kidneys)
Visual impairment

50-59:

Suicide attempt
Anxiety
Fall
Panic attack
Syncope (loss of consciousness with an inability to maintain postural tone)

60+:

Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Respiratory tract congestion (blockage on respiratory system)
Skin disorder (skin disease)
Skin fragility (trauma-induced blisters and erosions of skin)
Spinal fusion surgery
Urinary tract infection
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Arthralgia (joint pain)
Asthenia (weakness)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 42.31%
Asthma: 9 people, 34.62%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 26.92%
Drowsiness: 5 people, 19.23%
Immunodeficiency Common Variable: 3 people, 11.54%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 3 people, 11.54%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 2 people, 7.69%
Acute Coronary Syndrome (acute chest pain and other symptoms that happen because the heart does not get blood): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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