Tobramycin sulfate and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tobramycin sulfate (tobramycin sulfate) and Methotrexate (methotrexate sodium). Common drug interactions include stevens-johnson syndrome among females and petit mal epilepsy among males.

The phase IV clinical study analyzes what interactions people have when they take Tobramycin sulfate and Methotrexate. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Tobramycin sulfate?

Tobramycin sulfate has active ingredients of tobramycin sulfate. eHealthMe is studying from 581 Tobramycin sulfate users. Check the latest studies of Tobramycin sulfate.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,314 Methotrexate users. Check the latest studies of Methotrexate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

13 people who take Tobramycin sulfate and Methotrexate together, and have interactions are studied.

Tobramycin sulfate and Methotrexate drug interactions.

What are the common drug interactions of Tobramycin Sulfate and Methotrexate, by gender? *:

female:

Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Pulmonary oedema (fluid accumulation in the lungs)
Blood ph decreased
Cardiac failure
Cardiomegaly (increased size of heart than normal)
Cerebral haemorrhage (bleeding within the brain)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Clostridial infection (infectious conditions by clostridium bacteria)
Death

male:

Petit mal epilepsy (absence seizure)
Cardiac failure
Haemolytic anaemia (anaemia due to haemolysis)
Pharyngolaryngeal pain
Pleural infection (infection of membrane of lungs)
Pleurisy (inflammation of the pleurae, which causes pain when breathing)
Sore throat (pain or irritation of the throat)
Diarrhoea
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Hypokalaemia (low potassium)

What are the common drug interactions of Tobramycin Sulfate and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Petit mal epilepsy (absence seizure)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Pulmonary oedema (fluid accumulation in the lungs)
Respiratory distress (difficulty in breathing)

10-19:

Haemolytic anaemia (anaemia due to haemolysis)

20-29:

n/a

30-39:

n/a

40-49:

Cardiac failure
Diarrhoea
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Hypokalaemia (low potassium)
Hypoproteinaemia (too little prolactin circulating in the blood)
Pneumonia
Renal failure (kidney dysfunction)
Vomiting
Blood bilirubin increased
Pharyngolaryngeal pain

50-59:

Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

60+:

Blood ph decreased
Cardiac failure
Posterior reversible encephalopathy syndrome (posterior reversible encephalopathy syndrome (pres), also known as reversible posterior leukoencephalopathy syndrome (rpls), is a syndrome characterized by headache, confusion, seizures and visual loss)
Pulmonary oedema (fluid accumulation in the lungs)
Respiratory depression (respiration has a rate below 12 breaths)
Visual acuity reduced (reduced clearness of vision)
Weight increased
Cardiomegaly (increased size of heart than normal)
Clostridial infection (infectious conditions by clostridium bacteria)
Death

What are the existing conditions these people have? *

Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 4 people, 30.77%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 3 people, 23.08%
Hypocalcaemia (levels of calcium in blood serum are abnormally low): 2 people, 15.38%
Agitation (state of anxiety or nervous excitement): 2 people, 15.38%
Anaesthesia: 2 people, 15.38%
Bacterial Infection: 2 people, 15.38%
Bleeding Disorders: 2 people, 15.38%
Bronchopulmonary Aspergillosis (lung disorder caused by aspergillus fungi): 2 people, 15.38%
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 2 people, 15.38%
Dyspnea (difficult or laboured breathing): 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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