Tolvaptan and Cymbalta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tolvaptan (tolvaptan) and Cymbalta (duloxetine hydrochloride). Common drug interactions include polydipsia among females and cholecystitis among males.

The phase IV clinical study analyzes what interactions people have when they take Tolvaptan and Cymbalta. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Tolvaptan?

Tolvaptan has active ingredients of tolvaptan. eHealthMe is studying from 5,685 Tolvaptan users. Check the latest studies of Tolvaptan.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,973 Cymbalta users. Check the latest studies of Cymbalta.

On Jul, 04, 2026

21 people who take Tolvaptan and Cymbalta together, and have interactions are studied.

Tolvaptan and Cymbalta drug interactions.

What are the common drug interactions of Tolvaptan and Cymbalta, by gender? *:

female:

Polydipsia (excessive thirst)
Renal cyst ruptured (tear of renal cyst)
Confusional state
Vomiting
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Fall
Blood potassium increased
Renal impairment (severely reduced kidney function)
Blood sodium decreased
Thirst

male:

Cholecystitis (infection of gallbladder)
Disease progression
Renal cyst haemorrhage (bleeding kidney cyst)
Renal pain (kidney pain)

What are the common drug interactions of Tolvaptan and Cymbalta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anaemia (lack of blood)
Atelectasis (partial or complete collapse of the lung)
Bacterial test positive
Blood sodium decreased
Hydronephrosis (water inside the kidney)
Migraine (headache)
Nephrolithiasis (calculi in the kidneys)
Pleural effusion (water on the lungs)
Pyelonephritis (inflammation of kidney caused by bacteria)
Renal failure acute (rapid kidney dysfunction)

30-39:

Asthenia (weakness)
Nausea (feeling of having an urge to vomit)
Weight decreased
Drug intolerance (drug sensitivity)
Nocturia (the need to get up in the night to urinate)
Polydipsia (excessive thirst)
Renal cyst ruptured (tear of renal cyst)
Renal pain (kidney pain)
Confusional state
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)

40-49:

Renal cyst haemorrhage (bleeding kidney cyst)
Renal pain (kidney pain)
Anaemia (lack of blood)
C-reactive protein increased
Decreased appetite
Disease progression
Nephrolithiasis (calculi in the kidneys)
Pyrexia (fever)
Renal cyst infection (kidney cyst infection)
Renal impairment (severely reduced kidney function)

50-59:

Cholecystitis (infection of gallbladder)
Disease progression
Alanine aminotransferase increased
Aspartate aminotransferase increased
Hepatic enzyme increased
Thirst

60+:

Blood potassium increased
Fall
Renal impairment (severely reduced kidney function)
Contusion (a type of hematoma of tissue in which capillaries)
Dyspnoea (difficult or laboured respiration)
Tremor (trembling or shaking movements in one or more parts of your body)
Bone pain
Malignant neoplasm progression (cancer tumour came back)
Respiratory tract infection
Blood sodium decreased

What are the existing conditions these people have? *

Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 3 people, 14.29%
Pain: 2 people, 9.52%
Inappropriate Antidiuretic Hormone Secretion: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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