Topamax and Pentoxifylline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Topamax (topiramate) and Pentoxifylline (pentoxifylline). Common drug interactions include nausea among females and acidosis among males.

The phase IV clinical study analyzes what interactions people have when they take Topamax and Pentoxifylline. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Topamax?

Topamax has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 58,956 Topamax users. Check the latest studies of Topamax.

What is Pentoxifylline?

Pentoxifylline has active ingredients of pentoxifylline. eHealthMe is studying from 5,997 Pentoxifylline users. Check the latest studies of Pentoxifylline.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

22 people who take Topamax and Pentoxifylline together, and have interactions are studied.

Topamax and Pentoxifylline drug interactions.

What are the common drug interactions of Topamax and Pentoxifylline, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Back pain
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic kidney disease
Depressed mood
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Drug ineffective
Drug screen positive
Hemiparesis (weakness on one side of the body)

male:

Acidosis (build-up of carbon dioxide in the blood)
Ammonia increased
Hyperammonaemia
Hyperlipidaemia (presence of excess lipids in the blood)
Hypermetropia (abnormal condition in which vision for distant objects is better than for near objects)
Hyperosmolar state (life-threatening emergency manifested by marked elevation of blood glucose)
Hypertension (high blood pressure)
Presbyopia (a condition in which the lens of the eye loses its ability to focus, making it difficult to see objects up close)
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Spinal osteoarthritis (joint cartilage loss in spine)

What are the common drug interactions of Topamax and Pentoxifylline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chest discomfort
Diarrhoea
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Weight decreased

40-49:

Back pain
Chest pain
Chills (felling of cold)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Headache (pain in head)
Injection site discomfort
Injection site pain
Injury

50-59:

Acidosis (build-up of carbon dioxide in the blood)
Arteriosclerosis (thickening and hardening of arteries)
Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)
Bipolar disorder (mood disorder)
Cataract (clouding of the lens inside the eye)
Depression
Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypermetropia (abnormal condition in which vision for distant objects is better than for near objects)

60+:

Decreased appetite
Depressed mood
Fatigue (feeling of tiredness)
Hypoaesthesia (reduced sense of touch or sensation)
Tremor (trembling or shaking movements in one or more parts of your body)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 31.82%
Pain: 7 people, 31.82%
Stress And Anxiety: 6 people, 27.27%
Depression: 6 people, 27.27%
Dry Mouth: 4 people, 18.18%
Nausea (feeling of having an urge to vomit): 4 people, 18.18%
Irritable Bowel Syndrome: 4 people, 18.18%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 13.64%
Insomnia (sleeplessness): 3 people, 13.64%
Stable Angina (a constant chest pain): 3 people, 13.64%

* Approximation only. Some reports may have incomplete information.

Do you take Topamax and Pentoxifylline?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously