Tigan and Topamax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tigan (trimethobenzamide hydrochloride) and Topamax (topiramate). Common drug interactions include aplastic anaemia among females and disorientation among males.

The phase IV clinical study analyzes what interactions people have when they take Tigan and Topamax. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Tigan?

Tigan has active ingredients of trimethobenzamide hydrochloride. It is often used in nausea. eHealthMe is studying from 1,904 Tigan users. Check the latest studies of Tigan.

What is Topamax?

Topamax has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 58,951 Topamax users. Check the latest studies of Topamax.

On Oct, 19, 2025

34 people who take Tigan and Topamax together, and have interactions are studied.

What are the common drug interactions of Tigan and Topamax, by gender? *:

female:

Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Appendicitis (inflammation of the appendix)
Appetite disorder (abnormal eating habits)
Areflexia (absence of a reflex)
Fatigue (feeling of tiredness)
Asthenia (weakness)
Diarrhoea
Pain in extremity
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dyspnoea (difficult or laboured respiration)

male:

Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Pancreatitis (inflammation of pancreas)
Injection site pain
Injection site swelling
Memory impairment
Vertigo
Anger
Back injury
Balance disorder
Crying

What are the common drug interactions of Tigan and Topamax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Type 2 diabetes mellitus
Obesity (having too much body fat)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

20-29:

Ectopic pregnancy (a pregnancy in which the foetus develops outside the uterus, typically in a fallopian tube)
Fungal infection
Post-partum haemorrhage (bleeding in woman after she has given birth)
Pregnancy
Sinusitis (inflammation of sinus)

30-39:

Coma (state of unconsciousness lasting more than six hours)

40-49:

Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Pancreatitis (inflammation of pancreas)
Abnormal dreams
Drug screen positive
Fatigue (feeling of tiredness)
Injection site pain
Injection site swelling
Nervousness
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)
Rash

50-59:

Asthenia (weakness)
Dry throat
Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Cardiac failure congestive
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cerebral haemorrhage (bleeding within the brain)
Chest pain
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Diarrhoea

60+:

Anger
Asthenia (weakness)
Fall
Fatigue (feeling of tiredness)
Feeling cold
Fluid retention (an abnormal accumulation of fluid in the blood)
Hyperhidrosis (abnormally increased sweating)
Increased appetite
Memory impairment
Muscle spasms (muscle contraction)

What are the existing conditions these people have? *

Stress And Anxiety: 6 people, 17.65%
Type 2 Diabetes: 3 people, 8.82%
Pain: 3 people, 8.82%
Breakthrough Pain: 3 people, 8.82%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 8.82%
Agitation (state of anxiety or nervous excitement): 3 people, 8.82%
Parkinson's Disease: 3 people, 8.82%
Oedema (fluid collection in tissue): 2 people, 5.88%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 5.88%
High Blood Cholesterol: 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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