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Topamax and Wegovy drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Topamax (topiramate) and Wegovy (semaglutide). Common drug interactions include dental caries among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Topamax and Wegovy. It is created by eHealthMe based on reports of 9 people who take the same drugs from the FDA, and is updated regularly.

What is Topamax?

Topamax has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 58,954 Topamax users. Check the latest studies of Topamax.

What is Wegovy?

Wegovy has active ingredients of semaglutide. It is often used in weight loss. eHealthMe is studying from 4,885 Wegovy users. Check the latest studies of Wegovy.

On Apr, 15, 2026

9 people who take Topamax and Wegovy together, and have interactions are studied.

Topamax and Wegovy drug interactions.

What are the common drug interactions of Topamax and Wegovy, by gender? *:

female:

  1. Dental caries
  2. Dysaesthesia (abnormal sensation)
  3. Fall
  4. Fibromyalgia (a long-term condition which causes pain all over the body)
  5. Headache (pain in head)
  6. Nausea (feeling of having an urge to vomit)
  7. Pain of skin
  8. Pruritus (severe itching of the skin)
  9. Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
  10. Seizure (abnormal excessive or synchronous neuronal activity in the brain)

male:

  1. Anxiety
  2. Ligament sprain (ligament stretched)
  3. Seizure (abnormal excessive or synchronous neuronal activity in the brain)

What are the common drug interactions of Topamax and Wegovy, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Anxiety
  2. Ligament sprain (ligament stretched)
  3. Seizure (abnormal excessive or synchronous neuronal activity in the brain)

30-39:

n/a

40-49:

  1. Pruritus (severe itching of the skin)
  2. Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
  3. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  4. Urinary incontinence (inability to control the flow of urine and involuntary urination)
  5. Urticaria (rash of round, red welts on the skin that itch intensely)
  6. Blood pressure increased
  7. Burning sensation
  8. Cervical radiculopathy (disturbance of nerve function that causes pain in the upper body)
  9. Dental caries
  10. Dysaesthesia (abnormal sensation)

50-59:

  1. Fibromyalgia (a long-term condition which causes pain all over the body)
  2. Pain of skin

60+:

n/a

* Approximation only. Some reports may have incomplete information.

Do you take Topamax and Wegovy?

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Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Topamax and Wegovy:

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Browse all side effects of Topamax:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Wegovy:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Topamax and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Wegovy and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on topiramate and semaglutide (the active ingredients of Topamax and Wegovy, respectively), and Topamax and Wegovy (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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