Topiramate and Skelaxin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Topiramate (topiramate) and Skelaxin (metaxalone). Common drug interactions include vomiting among females and cyst among males.

The phase IV clinical study analyzes what interactions people have when they take Topiramate and Skelaxin. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Topiramate?

Topiramate has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 49,809 Topiramate users. Check the latest studies of Topiramate.

What is Skelaxin?

Skelaxin has active ingredients of metaxalone. It is often used in back pain. eHealthMe is studying from 9,706 Skelaxin users. Check the latest studies of Skelaxin.

On Jul, 05, 2026

68 people who take Topiramate and Skelaxin together, and have interactions are studied.

Topiramate and Skelaxin drug interactions.

What are the common drug interactions of Topiramate and Skelaxin, by gender? *:

female:

Vomiting
Renal failure (kidney dysfunction)
Anxiety disorder
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Drug hypersensitivity
Dysgeusia (disorder of the sense of taste)
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)

male:

Cyst (a closed sac)
Fibromyalgia (a long-term condition which causes pain all over the body)
Acute myeloid leukaemia recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent)
Acute myocardial infarction (acute heart attack)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrophy (wasting away of a part of the body)
Bone disorder
Bone pain

What are the common drug interactions of Topiramate and Skelaxin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hepatic enzyme increased
Hepatic neoplasm (liver tumour)
Hepatic steatosis (fatty liver disease)

20-29:

Bipolar disorder (mood disorder)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Hallucinations, mixed (sensations that appear real but are created by your mind -mixed)
Memory impairment

30-39:

Fatigue (feeling of tiredness)
Pyrexia (fever)
Chronic kidney disease
Food poisoning (poison in food)
Gastrointestinal infection (infection of stomach and intestine)
Headache (pain in head)
Myalgia (muscle pain)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nausea (feeling of having an urge to vomit)
Otitis media (inflammation of the middle ear)

40-49:

Alopecia (absence of hair from areas of the body)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic kidney disease
Drug ineffective
Dry mouth
Dyspepsia (indigestion)
Fall
Gait disturbance
Headache (pain in head)
Joint injury

50-59:

Carotid artery disease
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Exercise tolerance decreased
Fatigue (feeling of tiredness)
Femur fracture
Gait disturbance
Headache (pain in head)
Hyperacusis (disorder in loudness perception)
Joint stiffness

60+:

Visual impairment
Abasia (inability to walk)
Adrenal mass
Adrenal neoplasm (abnormal growth of adrenal gland)
Adverse drug reaction
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)

What are the existing conditions these people have? *

Pain: 17 people, 25.00%
Depression: 12 people, 17.65%
Stress And Anxiety: 11 people, 16.18%
Muscle Spasms (muscle contraction): 10 people, 14.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 13.24%
Headache (pain in head): 8 people, 11.76%
Nausea (feeling of having an urge to vomit): 8 people, 11.76%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 10.29%
Inflammation: 7 people, 10.29%
Neuralgia (pain in one or more nerves): 7 people, 10.29%

* Approximation only. Some reports may have incomplete information.

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