Tpn and Amphotericin b drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tpn (niacinamide; pyridoxine hydrochloride; tyrosine) and Amphotericin b (amphotericin b). Common drug interactions include shock among females and cardiac failure among males.

The phase IV clinical study analyzes what interactions people have when they take Tpn and Amphotericin b. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Tpn?

Tpn has active ingredients of niacinamide; pyridoxine hydrochloride; tyrosine. eHealthMe is studying from 1,581 Tpn users. Check the latest studies of Tpn.

What is Amphotericin b?

Amphotericin b has active ingredients of amphotericin b. It is often used in thrush. eHealthMe is studying from 16,275 Amphotericin b users. Check the latest studies of Amphotericin b.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

16 people who take Tpn and Amphotericin b together, and have interactions are studied.

Tpn and Amphotericin b drug interactions.

What are the common drug interactions of Tpn and Amphotericin B, by gender? *:

female:

Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Acute hepatic failure
Arrhythmia (irregular heartbeat)
Cardiac failure
Coagulopathy (blood's ability to clot is impaired)
Haemoperitoneum (presence of blood in the peritoneal cavity)
Haemorrhage intracranial (bleeding within the skull)
Hepatic failure (liver failure)
Hepatic necrosis (large portions of liver die off due to severe liver disease)
Herpes simplex (herpes simplex is a common viral infection)

male:

Cardiac failure
Sepsis (a severe blood infection that can lead to organ failure and death)
Chest discomfort
Wheezing (a high-pitched whistling sound made while you breath)
Hypertransaminasaemia
Meningitis cryptococcal (bacterial inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Pneumonia
Pneumonia bacterial (pneumonia associated with bacterial infection)
Polyuria (production of too much dilute urine)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

What are the common drug interactions of Tpn and Amphotericin B, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Ammonia increased
Anuria (failure of the kidneys to produce urine)
Arrhythmia (irregular heartbeat)
Blood glucose increased
Bradycardia (abnormally slow heart action)
Cardiac arrest
Cardiac death
Epstein-barr virus infection
Fluid overload (too much fluid in the blood)
Graft versus host disease in liver (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the liver)

20-29:

Anaemia (lack of blood)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
Vomiting

30-39:

Chest discomfort
Wheezing (a high-pitched whistling sound made while you breath)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Cardiac failure
Dyspnoea (difficult or laboured respiration)
Hepatic failure (liver failure)
Hypotension (abnormally low blood pressure)
Lip ulceration (ulcer of lip)
Multi-organ failure (multisystem organ failure)
Oliguria (not enough urine)

40-49:

n/a

50-59:

Acute hepatic failure
Coagulopathy (blood's ability to clot is impaired)
Haemoperitoneum (presence of blood in the peritoneal cavity)
Haemorrhage intracranial (bleeding within the skull)
Hepatic necrosis (large portions of liver die off due to severe liver disease)
Herpes simplex (herpes simplex is a common viral infection)
Herpes simplex hepatitis (inflammation of liver due to virus herpes simplex)
Hyperlactacidaemia (the acidosis and also reduces the capacity of the kidney)
Ischaemic hepatitis (decreased blood supply to the liver resulting in injury to liver cells)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

60+:

Cardiac failure
Sepsis (a severe blood infection that can lead to organ failure and death)
Delirium (wild excitement)
Hyperglycaemia (high blood sugar)
Hypokalaemia (low potassium)
Loss of consciousness
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pneumonia
Polyuria (production of too much dilute urine)
Alanine aminotransferase increased

What are the existing conditions these people have? *

Constipation: 6 people, 37.50%
Pneumonia: 6 people, 37.50%
High Blood Pressure: 5 people, 31.25%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 5 people, 31.25%
Flatulence (flatus expelled through the anus): 5 people, 31.25%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 25.00%
Hypokalemia (low potassium): 4 people, 25.00%
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood): 4 people, 25.00%
Diabetes: 4 people, 25.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 25.00%

* Approximation only. Some reports may have incomplete information.

Do you take Tpn and Amphotericin b?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously