Tracleer and Gemfibrozil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tracleer (bosentan) and Gemfibrozil (gemfibrozil). Common drug interactions include aspartate aminotransferase increased among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Tracleer and Gemfibrozil. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Tracleer?

Tracleer has active ingredients of bosentan. It is often used in primary pulmonary hypertension. eHealthMe is studying from 55,125 Tracleer users. Check the latest studies of Tracleer.

What is Gemfibrozil?

Gemfibrozil has active ingredients of gemfibrozil. It is often used in high blood cholesterol. eHealthMe is studying from 18,213 Gemfibrozil users. Check the latest studies of Gemfibrozil.

On Jul, 03, 2026

20 people who take Tracleer and Gemfibrozil together, and have interactions are studied.

Tracleer and Gemfibrozil drug interactions.

What are the common drug interactions of Tracleer and Gemfibrozil, by gender? *:

female:

Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Drug ineffective
Fluid overload (too much fluid in the blood)
Oedema peripheral (superficial swelling)
Alanine aminotransferase increased
Dyspnoea exertional (breathlessness or shortness of breath)
Urinary tract infection
Abdominal discomfort
Abdominal distension

male:

Diarrhoea
Flushing (the warm, red condition of human skin)
Adverse event
Secretion discharge
Blood glucose increased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Fall
Foot fracture
Limb injury
Squamous cell carcinoma (a cancer of a kind of epithelial cell)

What are the common drug interactions of Tracleer and Gemfibrozil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Acute right ventricular failure (acute heart attack)
Ascites (accumulation of fluid in the abdominal cavity)
Cardiac failure
Chest discomfort
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Lung disorder (lung disease)
Oedema peripheral (superficial swelling)
Pulmonary hypertension (increase in blood pressure in the lung artery)

60+:

Flushing (the warm, red condition of human skin)
Diarrhoea
Blood alkaline phosphatase increased
Drug ineffective
Tooth infection
Dyspnoea (difficult or laboured respiration)
Fall
Adverse event
Alanine aminotransferase increased
Oedema peripheral (superficial swelling)

What are the existing conditions these people have? *

Pulmonary Hypertension (increase in blood pressure in the lung artery): 4 people, 20.00%
Essential Hypertension (primary hypertension): 4 people, 20.00%
Right Ventricular Failure (right half of the heart fails to work): 3 people, 15.00%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 5.00%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 5.00%
Metabolic Syndrome (a combination of the medical disorders that, when occurring together, increase the risk of developing cardiovascular disease): 1 person, 5.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.00%
Dizziness: 1 person, 5.00%
Diabetes: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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