Tradjenta and Opsumit drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tradjenta (linagliptin) and Opsumit (macitentan). Common drug interactions include chemotherapy among females and stent placement among males.

The phase IV clinical study analyzes what interactions people have when they take Tradjenta and Opsumit. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Tradjenta?

Tradjenta has active ingredients of linagliptin. It is often used in diabetes. eHealthMe is studying from 9,987 Tradjenta users. Check the latest studies of Tradjenta.

What is Opsumit?

Opsumit has active ingredients of macitentan. eHealthMe is studying from 67,926 Opsumit users. Check the latest studies of Opsumit.

On Aug, 03, 2026

48 people who take Tradjenta and Opsumit together, and have interactions are studied.

Tradjenta and Opsumit drug interactions.

What are the common drug interactions of Tradjenta and Opsumit, by gender? *:

female:

Chemotherapy
Cholecystitis infective (infection of gallbladder capable to infect other organs)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Coronary arterial stent insertion
Dermatillomania (skin picking disorders)
Dry mouth
Dysgeusia (disorder of the sense of taste)
Dysstasia (difficulty in standing)
Gallbladder operation
General physical health deterioration (weak health status)

male:

Stent placement
Pyrexia (fever)
Oedema peripheral (superficial swelling)
Vertigo
Weight increased
Drug hypersensitivity
Eye swelling
Lacrimation increased
Abdominal pain upper
Adverse event

What are the common drug interactions of Tradjenta and Opsumit, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Dermatillomania (skin picking disorders)
Increased appetite

40-49:

n/a

50-59:

Hospitalisation
Asthenia (weakness)
Dry mouth
Dysgeusia (disorder of the sense of taste)
Dysstasia (difficulty in standing)
Fluid retention (an abnormal accumulation of fluid in the blood)
Heart rate irregular
Hypokalaemia (low potassium)
Loss of consciousness
Migraine (headache)

60+:

Dyspnoea (difficult or laboured respiration)
Oedema peripheral (superficial swelling)
Chills (felling of cold)
Arrhythmia (irregular heartbeat)
Dyspepsia (indigestion)
Haemorrhage (bleeding)
Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)
Pain in extremity
Purpura (purplish discoloration of the skin)
Vomiting

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 42 people, 87.50%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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