Tramadol hydrochloride and Estradiol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tramadol hydrochloride (tramadol hydrochloride) and Estradiol (estradiol). Common drug interactions include colitis ischaemic among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Tramadol hydrochloride and Estradiol. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Tramadol hydrochloride?

Tramadol hydrochloride has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 40,749 Tramadol hydrochloride users. Check the latest studies of Tramadol hydrochloride.

What is Estradiol?

Estradiol has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 18,986 Estradiol users. Check the latest studies of Estradiol.

On Jul, 18, 2026

38 people who take Tramadol hydrochloride and Estradiol together, and have interactions are studied.

Tramadol hydrochloride and Estradiol drug interactions.

What are the common drug interactions of Tramadol Hydrochloride and Estradiol, by gender? *:

female:

Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Confusional state
Constipation
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Dizziness
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Abdominal pain
Asthenia (weakness)

male:

Drug ineffective
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Infusion related reaction
Infusion site erythema (reddening of the skin at infusion site)
Infusion site pain
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Sinusitis (inflammation of sinus)
Thyroid neoplasm (tumour of thyroid)
Upper respiratory tract infection
Sinus bradycardia (an unusually slow heartbeat due to heart disease)

What are the common drug interactions of Tramadol Hydrochloride and Estradiol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Accidental exposure
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chills (felling of cold)
Drug ineffective
Headache (pain in head)
Infusion related reaction
Infusion site erythema (reddening of the skin at infusion site)
Infusion site pain
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)

10-19:

n/a

20-29:

Fatigue (feeling of tiredness)
Abdominal pain
Abdominal rigidity
Blood sodium decreased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Enteritis (inflammation of the small intestine)
Haematochezia (passage of stools containing blood)
Intestinal perforation (complete penetration of the wall of the intestine)
Malaise (a feeling of general discomfort or uneasiness)

30-39:

n/a

40-49:

Abdominal pain
Asthenia (weakness)
Dizziness
Fatigue (feeling of tiredness)
Headache (pain in head)
Oedema (fluid collection in tissue)
Blood potassium decreased
Bone pain
Colitis (inflammation of colon)
Local swelling (swelling at the site of some application of substance or injury)

50-59:

Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pancreatitis (inflammation of pancreas)
Panic attack
Poor quality sleep
Presyncope
Proteinuria (presence of protein in the urine)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Pulmonary embolism (blockage of the main artery of the lung)

60+:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Drug ineffective
Acute respiratory failure
Asthenia (weakness)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Decreased appetite

What are the existing conditions these people have? *

High Blood Pressure: 6 people, 15.79%
Osteoporosis (bones weak and more likely to break): 5 people, 13.16%
Nausea (feeling of having an urge to vomit): 4 people, 10.53%
Stress And Anxiety: 4 people, 10.53%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 10.53%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 10.53%
Headache (pain in head): 4 people, 10.53%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 10.53%
Muscle Spasms (muscle contraction): 3 people, 7.89%
Depression: 3 people, 7.89%

* Approximation only. Some reports may have incomplete information.

Do you take Tramadol hydrochloride and Estradiol?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously