Tramadol hydrochloride and Nitrostat drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tramadol hydrochloride (tramadol hydrochloride) and Nitrostat (nitroglycerin). Common drug interactions include balance disorder among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Tramadol hydrochloride and Nitrostat. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Tramadol hydrochloride?

Tramadol hydrochloride has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 40,749 Tramadol hydrochloride users. Check the latest studies of Tramadol hydrochloride.

What is Nitrostat?

Nitrostat has active ingredients of nitroglycerin. It is often used in chest pain. eHealthMe is studying from 14,082 Nitrostat users. Check the latest studies of Nitrostat.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

92 people who take Tramadol hydrochloride and Nitrostat together, and have interactions are studied.

Tramadol hydrochloride and Nitrostat drug interactions.

What are the common drug interactions of Tramadol Hydrochloride and Nitrostat, by gender? *:

female:

Balance disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Burning sensation
Diarrhoea
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Headache (pain in head)
Laryngeal inflammation (infection of larynx)
Limb discomfort (discomfort in leg)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nasopharyngitis (inflammation of the nasopharynx)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Death
Pain in extremity
Asthenia (weakness)
Breath sounds
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Cough
Drug hypersensitivity
Fall

What are the common drug interactions of Tramadol Hydrochloride and Nitrostat, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Depression
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Death
Nephropathy (damage to or disease of a kidney)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Renal impairment (severely reduced kidney function)

50-59:

Myalgia (muscle pain)
Nephropathy (damage to or disease of a kidney)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Impaired gastric emptying
Abdominal distension
Abdominal pain upper
Agitation (state of anxiety or nervous excitement)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Angiopathy (generic term for a disease of the blood vessels)
Appetite disorder (abnormal eating habits)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Atrioventricular block (heart block)
Burning sensation
Dizziness
Influenza
Memory impairment
Muscular weakness (muscle weakness)
Vomiting
Weight decreased

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 30 people, 32.61%
High Blood Pressure: 23 people, 25.00%
Stress And Anxiety: 17 people, 18.48%
High Blood Cholesterol: 16 people, 17.39%
Cardiac Disorder: 16 people, 17.39%
Diabetes: 15 people, 16.30%
Depression: 13 people, 14.13%
Stable Angina (a constant chest pain): 12 people, 13.04%
Indigestion: 12 people, 13.04%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 10 people, 10.87%

* Approximation only. Some reports may have incomplete information.

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