Amoxicillin and Injection site irritation - a phase IV clinical study of FDA data

Summary:

Injection site irritation is reported as a side effect among people who take Amoxicillin (amoxicillin), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Methotrexate, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Injection site irritation when taking Amoxicillin. It is created by eHealthMe based on reports of 95,831 people who have side effects when taking Amoxicillin from the FDA, and is updated regularly.

What is Amoxicillin?

Amoxicillin has active ingredients of amoxicillin. It is often used in infection. eHealthMe is studying from 99,235 Amoxicillin users. Check the latest studies of Amoxicillin.

What is Injection site irritation?

Injection site irritation is found to be associated with 452 drugs and 511 conditions by eHealthMe. Check the latest studies of Injection site irritation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

95,831 people reported to have side effects when taking Amoxicillin.
Among them, 14 people (0.01%) have Injection site irritation.

Could Amoxicillin cause Injection site irritation?

Among these 14 people:

How long have people been on Amoxicillin when they have Injection site irritation? *

What is the gender of people who have Injection site irritation when taking Amoxicillin? *

female: 69.23 %
male: 30.77 %

What is the age of people who have Injection site irritation when taking Amoxicillin? *

What are other drugs people take besides Amoxicillin? *

What are other side effects people have besides Injection site irritation? *

Wound Infection: 4 people, 28.57%
Swelling: 4 people, 28.57%
Localised Infection (infection at the single location): 4 people, 28.57%
Kidney Infection: 4 people, 28.57%
Drug Hypersensitivity: 4 people, 28.57%
Weight Increased: 4 people, 28.57%
Post Procedural Infection: 4 people, 28.57%
Injection Site Pruritus (severe itching at injection site): 3 people, 21.43%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 21.43%
Pain: 3 people, 21.43%

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 4 people, 28.57%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 21.43%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 14.29%
Asthma: 2 people, 14.29%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 2 people, 14.29%
Dry Eyes (lack of adequate tears): 2 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 14.29%
High Blood Cholesterol: 2 people, 14.29%
High Blood Pressure: 2 people, 14.29%
Uveitis (inflammation of the uvea): 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Amoxicillin and have Injection site irritation?

- Check whether Injection site irritation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Amoxicillin:

Amoxicillin (99,235 reports)

Browse all side effects of Amoxicillin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Injection site irritation:

Injection site irritation (452 drugs)

Browse all the conditions that are associated with Injection site irritation:

Injection site irritation (511 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on amoxicillin (the active ingredients of Amoxicillin) and Amoxicillin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.