Tramadol and Epiduo drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tramadol (tramadol hydrochloride) and Epiduo (adapalene; benzoyl peroxide). Common drug interactions include colitis among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Tramadol and Epiduo. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,798 Tramadol users. Check the latest studies of Tramadol.

What is Epiduo?

Epiduo has active ingredients of adapalene; benzoyl peroxide. It is often used in acne. eHealthMe is studying from 1,581 Epiduo users. Check the latest studies of Epiduo.

On Jul, 17, 2026

31 people who take Tramadol and Epiduo together, and have interactions are studied.

What are the common drug interactions of Tramadol and Epiduo, by gender? *:

female:

Colitis (inflammation of colon)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hypercoagulation (increased tendency for clotting of the blood)
Neuralgia (pain in one or more nerves)
Adverse event
Colitis ulcerative (inflammation of colon with ulcer)
Discomfort
Drug hypersensitivity
Implant site pain

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood creatinine increased
Chronic kidney disease
Cystic fibrosis (disease of the secretary glands)
Dyspnoea (difficult or laboured respiration)
Emotional distress
Renal impairment (severely reduced kidney function)

What are the common drug interactions of Tramadol and Epiduo, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Post procedural complication
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hypercoagulation (increased tendency for clotting of the blood)
Neuralgia (pain in one or more nerves)
Suicidal ideation
Colitis (inflammation of colon)
Drug hypersensitivity
Retching (strong involuntary effort to vomit)
Skin irritation

30-39:

Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Headache (pain in head)
Hypersensitivity
White blood cell count decreased
Adverse event
Discomfort
Implant site pain

40-49:

Therapeutic response unexpected

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood creatinine increased
Chronic kidney disease
Emotional distress
Renal impairment (severely reduced kidney function)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 23 people, 74.19%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 17 people, 54.84%
Birth Control: 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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