Trandolapril and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trandolapril (trandolapril) and Actos (pioglitazone hydrochloride). Common drug interactions include hypoaesthesia among females and angina pectoris among males.

The phase IV clinical study analyzes what interactions people have when they take Trandolapril and Actos. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Trandolapril?

Trandolapril has active ingredients of trandolapril. It is often used in high blood pressure. eHealthMe is studying from 2,682 Trandolapril users. Check the latest studies of Trandolapril.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

On Aug, 11, 2026

21 people who take Trandolapril and Actos together, and have interactions are studied.

Trandolapril and Actos drug interactions.

What are the common drug interactions of Trandolapril and Actos, by gender? *:

female:

Hypoaesthesia (reduced sense of touch or sensation)
Listless (lack of interest, energy, or spirit)
Malaise (a feeling of general discomfort or uneasiness)
Metabolic disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues)
Mitochondrial myopathy (the muscle fibres do not function due to damage of mitochondria)
Neonatal respiratory distress syndrome (a serious medical condition where a newborn baby's lungs cannot provide their body with enough oxygen)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Skin chapped
Sudden infant death syndrome
Decreased appetite

male:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Arteriosclerosis (thickening and hardening of arteries)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Nystagmus (a condition of involuntary eye movement)
Oedema peripheral (superficial swelling)
Pleural effusion (water on the lungs)
Pruritus (severe itching of the skin)
Fall
Hepatitis cholestatic (flow of bile from the liver is slowed or blocked)
Hepatocellular damage (liver damage)

What are the common drug interactions of Trandolapril and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Weight increased
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Pruritus (severe itching of the skin)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Hepatitis cholestatic (flow of bile from the liver is slowed or blocked)
Hepatocellular damage (liver damage)
Pneumonia
Abdominal pain
Alanine aminotransferase increased
Antinuclear factor positive

50-59:

Abdominal distension
Blood cholesterol increased
Blood glucose increased
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Dyspepsia (indigestion)
Eructation (release of gas from the digestive tract)
Flatulence (flatus expelled through the anus)

60+:

Hypoglycaemia (deficiency of glucose in the bloodstream)
Arteriosclerosis (thickening and hardening of arteries)
Nystagmus (a condition of involuntary eye movement)
Oedema peripheral (superficial swelling)
Pleural effusion (water on the lungs)
Depressed level of consciousness
Malaise (a feeling of general discomfort or uneasiness)
Altered state of consciousness (altered state of mind)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Alopecia (absence of hair from areas of the body)

What are the existing conditions these people have? *

Type 2 Diabetes: 5 people, 23.81%
Sleep Disorder: 4 people, 19.05%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 3 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 14.29%
High Blood Cholesterol: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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