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Trandolapril and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trandolapril (trandolapril) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include somnolence among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Trandolapril and Benadryl. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Trandolapril?

Trandolapril has active ingredients of trandolapril. It is often used in high blood pressure. eHealthMe is studying from 2,682 Trandolapril users. Check the latest studies of Trandolapril.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

On Jul, 10, 2026

50 people who take Trandolapril and Benadryl together, and have interactions are studied.

Trandolapril and Benadryl drug interactions.

What are the common drug interactions of Trandolapril and Benadryl, by gender? *:

female:

  1. Somnolence (a state of near-sleep, a strong desire for sleep)
  2. Dizziness
  3. Vaginal haemorrhage (vaginal bleeding)
  4. Abdominal pain
  5. Abscess (pus)
  6. Blood pressure decreased
  7. Fatigue (feeling of tiredness)
  8. Flushing (the warm, red condition of human skin)
  9. Haematocrit decreased
  10. Intestinal perforation (complete penetration of the wall of the intestine)

male:

  1. Abdominal distension
  2. Cough
  3. Hyperaemia (increase of blood flow to different tissues in the body)
  4. Hypophagia (reduced food intake)
  5. Ileus (a painful obstruction of the ileum or other part of the intestine)
  6. Infrequent bowel movements
  7. Intestinal stenosis (partial obstruction that causes the centre opening of the intestine to become narrower)
  8. Accident
  9. Body temperature fluctuation
  10. Malaise (a feeling of general discomfort or uneasiness)

What are the common drug interactions of Trandolapril and Benadryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Vaginal haemorrhage (vaginal bleeding)
  2. Abdominal pain
  3. Abscess (pus)
  4. Blood pressure decreased
  5. Dizziness
  6. Fatigue (feeling of tiredness)
  7. Flushing (the warm, red condition of human skin)
  8. Haematocrit decreased
  9. Intestinal perforation (complete penetration of the wall of the intestine)
  10. Mobility decreased (ability to move is reduced)

40-49:

  1. Abdominal distension
  2. Cough
  3. Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
  4. Night sweats (sweating in night)
  5. Abdominal pain
  6. Aphthous ulcer (mouth ulcer)
  7. C-reactive protein increased
  8. Diarrhoea
  9. Drug specific antibody present
  10. Gastrointestinal disorder (functional problems of gastrointestinal tract)

50-59:

  1. Hypoxia (low oxygen in tissues)
  2. Pneumonitis (inflammation of the walls of the alveoli in the lungs)
  3. Alopecia (absence of hair from areas of the body)
  4. Eye pruritus (eye itching)
  5. Ocular hyperaemia (an abnormally large amount of blood in eye)

60+:

  1. Cough
  2. Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
  3. Psychotic disorder
  4. Renal cyst (kidney cyst)
  5. Somnolence (a state of near-sleep, a strong desire for sleep)
  6. Throat irritation
  7. Urinary tract infection
  8. Blood sodium decreased
  9. Chronic kidney disease
  10. Dizziness

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 21 people, 42.00%
  2. Helicobacter Infection (helicobacter pylori (h. pylori) infects stomach): 8 people, 16.00%
  3. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 8 people, 16.00%
  4. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 7 people, 14.00%
  5. High Blood Cholesterol: 5 people, 10.00%
  6. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 10.00%
  7. Vasculitis (inflammation of a blood vessel or blood vessels): 4 people, 8.00%
  8. Type 2 Diabetes: 4 people, 8.00%
  9. Pain: 4 people, 8.00%
  10. Itching: 4 people, 8.00%

* Approximation only. Some reports may have incomplete information.

Do you take Trandolapril and Benadryl?

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- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Trandolapril and Benadryl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Trandolapril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Benadryl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Trandolapril and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Benadryl and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on trandolapril and diphenhydramine hydrochloride (the active ingredients of Trandolapril and Benadryl, respectively), and Trandolapril and Benadryl (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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