Transderm scop and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Transderm scop (scopolamine) and Methotrexate (methotrexate sodium). Common drug interactions include back pain among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Transderm scop and Methotrexate. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Transderm scop?

Transderm scop has active ingredients of scopolamine. It is often used in motion sickness. eHealthMe is studying from 3,011 Transderm scop users. Check the latest studies of Transderm scop.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 05, 2026

43 people who take Transderm scop and Methotrexate together, and have interactions are studied.

Transderm scop and Methotrexate drug interactions.

What are the common drug interactions of Transderm Scop and Methotrexate, by gender? *:

female:

Back pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cystitis (inflammation of the wall of the bladder)
Depression
Diarrhoea
Drug ineffective
Migraine (headache)
Pain in extremity
Somnolence (a state of near-sleep, a strong desire for sleep)
Abdominal discomfort

male:

Abdominal pain
Blood bilirubin increased
Agitation (state of anxiety or nervous excitement)
Ammonia increased
Apnoea (suspension of external breathing)
Atelectasis (partial or complete collapse of the lung)
Chest discomfort
Clonus (series of involuntary, rhythmic, muscular contractions and relaxations)
Coagulopathy (blood's ability to clot is impaired)
Confusional state

What are the common drug interactions of Transderm Scop and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Encephalopathy (functioning of the brain is affected by some agent or condition)
Fluid overload (too much fluid in the blood)
Gallbladder enlargement
Gastrointestinal oedema (excessive build-up of fluid in the gastrointestinal tract tissues)
Hallucination (an experience involving the perception of something not present)
Headache (pain in head)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic failure (liver failure)
Hepatomegaly (abnormal enlargement of the liver)
Hyperbilirubinaemia (excess of bilirubin in the blood)

20-29:

Hepatobiliary disease (diseases affect the liver and/or biliary tract)
Joint range of motion decreased (disease of joint movement)
Mobility decreased (ability to move is reduced)

30-39:

n/a

40-49:

Anxiety
Benign neoplasm of adrenal gland (benign (non-cancerous) tumours of the adrenal gland)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cervix carcinoma (cancer of cervix)
Depression
Hepatomegaly (abnormal enlargement of the liver)
Immune system disorder
Injection site swelling
Mass
Migraine (headache)

50-59:

Wrist surgery
Anxiety
Arthralgia (joint pain)
Blood cholesterol increased
Depression
Nystagmus (a condition of involuntary eye movement)
Oral torus (a lesion made of compact bone and occurs along the palate or the mandible inside the mouth)
Osteonecrosis (death of bone)
Pulmonary embolism (blockage of the main artery of the lung)
Respiratory failure (inadequate gas exchange by the respiratory system)

60+:

Back pain
Diarrhoea
Blood potassium increased
Blood pressure decreased
Blood pressure increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Carbon dioxide increased
Cardioversion
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Colitis (inflammation of colon)

What are the existing conditions these people have? *

Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 11 people, 25.58%
Pain: 11 people, 25.58%
Nausea (feeling of having an urge to vomit): 10 people, 23.26%
Constipation: 9 people, 20.93%
Indigestion: 7 people, 16.28%
Nausea And Vomiting: 6 people, 13.95%
Depression: 5 people, 11.63%
Nervous System Disorder (a general class of medical conditions affecting the nervous system): 5 people, 11.63%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 11.63%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 11.63%

* Approximation only. Some reports may have incomplete information.

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