Trazodone hydrochloride and Serzone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trazodone hydrochloride (trazodone hydrochloride) and Serzone (nefazodone hydrochloride). Common drug interactions include cognitive disorder among females and hyperlipidaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Trazodone hydrochloride and Serzone. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Trazodone hydrochloride?

Trazodone hydrochloride has active ingredients of trazodone hydrochloride. It is often used in insomnia. eHealthMe is studying from 23,016 Trazodone hydrochloride users. Check the latest studies of Trazodone hydrochloride.

What is Serzone?

Serzone has active ingredients of nefazodone hydrochloride. It is often used in depression. eHealthMe is studying from 7,695 Serzone users. Check the latest studies of Serzone.

On Jul, 04, 2026

27 people who take Trazodone hydrochloride and Serzone together, and have interactions are studied.

Trazodone hydrochloride and Serzone drug interactions.

What are the common drug interactions of Trazodone Hydrochloride and Serzone, by gender? *:

female:

Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Hypersensitivity
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Hyperglycaemia (high blood sugar)
Neuropathy peripheral (surface nerve damage)
Type 1 diabetes mellitus
Type 2 diabetes mellitus

male:

Hyperlipidaemia (presence of excess lipids in the blood)
Weight increased
Oedema peripheral (superficial swelling)
Osteonecrosis of jaw (death of bone of jaw)
Pain
Pain in extremity
Pneumonia
Pyrexia (fever)
Renal failure acute (rapid kidney dysfunction)
Spinal osteoarthritis (joint cartilage loss in spine)

What are the common drug interactions of Trazodone Hydrochloride and Serzone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hypersensitivity

30-39:

Abnormal dreams
Back pain
Fluid retention (an abnormal accumulation of fluid in the blood)
Polydipsia (excessive thirst)
Thirst
Weight increased

40-49:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Ascites (accumulation of fluid in the abdominal cavity)
Blood creatinine increased
Blood potassium decreased
Delirium (wild excitement)
Dementia (madness)
Diabetic hyperosmolar coma (diabetes coma due to extremely high blood sugar (glucose) levels; extreme lack of water (dehydration))
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Electrolyte imbalance
Encephalopathy (functioning of the brain is affected by some agent or condition)

50-59:

Blood cholesterol increased
Bone disorder
Cardiac failure congestive
Cardiac valve abscess (pus containing infection of heart valve)
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Conjunctivitis (pink eye)
Constipation
Corneal abrasion (loss of the surface of cornea)
Decreased interest
Deformity (disfigurement)

60+:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthralgia (joint pain)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypoaesthesia (reduced sense of touch or sensation)
Injury
Intervertebral disc degeneration (spinal disc degeneration)
Malaise (a feeling of general discomfort or uneasiness)
Oedema peripheral (superficial swelling)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteonecrosis of jaw (death of bone of jaw)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 14 people, 51.85%
Pain: 3 people, 11.11%
Stress And Anxiety: 2 people, 7.41%
Quit Smoking: 2 people, 7.41%
Prostate Cancer: 2 people, 7.41%
Gout (uric acid crystals building up in the body): 2 people, 7.41%
Bone Density Abnormal: 2 people, 7.41%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 2 people, 7.41%
Bipolar Disorder (mood disorder): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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