Tresiba and Naprosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tresiba (insulin degludec) and Naprosyn (naproxen). Common drug interactions include oedema peripheral among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Tresiba and Naprosyn. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Tresiba?

Tresiba has active ingredients of insulin degludec. It is often used in type 1 diabetes. eHealthMe is studying from 20,677 Tresiba users. Check the latest studies of Tresiba.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

On Jul, 19, 2026

24 people who take Tresiba and Naprosyn together, and have interactions are studied.

What are the common drug interactions of Tresiba and Naprosyn, by gender? *:

female:

Oedema peripheral (superficial swelling)
Oral mucosal erythema (redness of the mucous membrane of mouth)
Osteomyelitis (infection of bone)
Palpitations (feelings or sensations that your heart is pounding or racing)
Panic attack
Pathological fracture (broken bone caused by disease)
Productive cough
Rales (an abnormal respiratory sound characterized by fine crackles)
Respiratory disorder (respiratory disease)
Respiratory rate increased (excess breathing rate/min)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Impaired work ability
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Weight decreased
Abscess limb (limb infection)
Anal abscess
Cellulitis (infection under the skin)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

What are the common drug interactions of Tresiba and Naprosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Nephrogenic anaemia (anaemia due to kidney disease)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Anxiety
Depression
Suicidal ideation
Suicide attempt
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

50-59:

Cellulitis (infection under the skin)
Genital abscess (build up of pus in genital)
Groin abscess (pus in groin)
Hepatic cancer stage iv
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Pancreatic carcinoma stage iv (pancreatic cancer stage iv)
Perineal abscess
Scrotal abscess (pus in scrotum)
Secondary hyperthyroidism

60+:

Bone loss
Cardiomegaly (increased size of heart than normal)
Neuropathy peripheral (surface nerve damage)
Non-hodgkin's lymphoma (malignant (cancer) cells form in the lymph system)
Osteonecrosis of jaw (death of bone of jaw)
Ovarian cyst (fluid filled sac of the ovary)
Periarthritis (inflammation of the external coats of an artery and of the tissues around the artery)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Quality of life decreased
Road traffic accident

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 16 people, 66.67%
Blood Pressure Abnormal: 12 people, 50.00%
High Blood Cholesterol: 10 people, 41.67%
Sleep Disorder: 10 people, 41.67%
Diabetes: 8 people, 33.33%
Cardiac Disorder: 7 people, 29.17%
High Blood Pressure: 7 people, 29.17%
Gout (uric acid crystals building up in the body): 7 people, 29.17%
Headache (pain in head): 3 people, 12.50%
Metastases To Bone (cancer spreads to bone): 3 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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