Tretinoin and Methylphenidate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tretinoin (tretinoin) and Methylphenidate (methylphenidate). Common drug interactions include keratitis among females and lymphadenopathy among males.

The phase IV clinical study analyzes what interactions people have when they take Tretinoin and Methylphenidate. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Tretinoin?

Tretinoin has active ingredients of tretinoin. It is often used in acne. eHealthMe is studying from 6,479 Tretinoin users. Check the latest studies of Tretinoin.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,216 Methylphenidate users. Check the latest studies of Methylphenidate.

On Aug, 07, 2026

51 people who take Tretinoin and Methylphenidate together, and have interactions are studied.

Tretinoin and Methylphenidate drug interactions.

What are the common drug interactions of Tretinoin and Methylphenidate, by gender? *:

female:

Keratitis (eye's cornea, the front part of the eye, becomes inflamed)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Malaise (a feeling of general discomfort or uneasiness)
Melanocytic naevus (a type of lesion that contains nevus cells (a type of melanocyte))
Muscular weakness (muscle weakness)
Nephrolithiasis (calculi in the kidneys)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Psoriasis (immune-mediated disease that affects the skin)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Schizoaffective disorder bipolar type (mental illness featuring schizophrenia and a mood disorder with mania)

male:

Lymphadenopathy (disease or enlargement of lymph nodes)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Bone density decreased
Bone loss
Emotional distress
Pain
Tooth loss
Eye disorder
Gastrointestinal obstruction
Gastrointestinal pain

What are the common drug interactions of Tretinoin and Methylphenidate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Lymphadenopathy (disease or enlargement of lymph nodes)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Precocious puberty
Skin papilloma (a general medical term for a tumour of the skin or mucous membrane with finger-like projections)
Surgery
Anxiety
Dyskinesia (abnormality or impairment of voluntary movement)
Scoliosis (a medical condition in which a person's spine is curved from side to side)

10-19:

n/a

20-29:

Nausea (feeling of having an urge to vomit)
Vomiting
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dehydration (dryness resulting from the removal of water)
Discomfort
Dizziness
Drug hypersensitivity
Drug ineffective
Fatigue (feeling of tiredness)
Feeling cold

30-39:

Migraine (headache)
Abdominal discomfort
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Depression
Drug ineffective
Food allergy
Fungal infection
Headache (pain in head)
Ligament sprain (ligament stretched)
Micturition urgency (urgency to pass the urine)

40-49:

Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Hysterectomy
Gastrointestinal obstruction
Gastrointestinal pain
Haematochezia (passage of stools containing blood)
Irritable bowel syndrome
Mood swings (an extreme or rapid change in mood)
Abdominal pain
Influenza like illness
Injection site pruritus (severe itching at injection site)

50-59:

Depression
Dyspnoea (difficult or laboured respiration)
Histoplasmosis (infection caused by breathing in spores of a fungus)
Hydrocephalus (water on the brain)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypersomnia (excessive daytime sleepiness (eds))
Migraine (headache)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Weight decreased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)

60+:

Cataract (clouding of the lens inside the eye)
Cellulitis (infection under the skin)
Hip arthroplasty
Muscle spasms (muscle contraction)
Uterine disorder

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 40 people, 78.43%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 20 people, 39.22%
Drowsiness: 18 people, 35.29%
Stress And Anxiety: 3 people, 5.88%
Pain: 3 people, 5.88%
Nausea (feeling of having an urge to vomit): 3 people, 5.88%
Depression: 3 people, 5.88%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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