Trexall and Omeprazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trexall (methotrexate sodium) and Omeprazole (omeprazole). Common drug interactions include chronic kidney disease among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Trexall and Omeprazole. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Trexall?

Trexall has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 1,439 Trexall users. Check the latest studies of Trexall.

What is Omeprazole?

Omeprazole has active ingredients of omeprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 410,631 Omeprazole users. Check the latest studies of Omeprazole.

On Jul, 20, 2026

32 people who take Trexall and Omeprazole together, and have interactions are studied.

Trexall and Omeprazole drug interactions.

What are the common drug interactions of Trexall and Omeprazole, by gender? *:

female:

Chronic kidney disease
Localised intraabdominal fluid collection (collection of fluid in abdomen in single site)
Renal failure (kidney dysfunction)
Transaminases increased
Alopecia (absence of hair from areas of the body)
Anaphylactic reaction (serious allergic reaction)
Body height decreased
Breast cancer in situ
Change of bowel habit
Death

male:

Anaemia (lack of blood)
Ascites (accumulation of fluid in the abdominal cavity)
Leukocytosis (increased white blood cells)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Sepsis (a severe blood infection that can lead to organ failure and death)
Abdominal wall cyst (abnormal membranous sac containing a gaseous, liquid, or semisolid substance on abdominal wall)
Abscess limb (limb infection)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bladder cyst

What are the common drug interactions of Trexall and Omeprazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chills (felling of cold)
Fatigue (feeling of tiredness)
Pyrexia (fever)
Nausea (feeling of having an urge to vomit)
Abdominal distension
Abdominal hernia
Abdominal mass (localized enlargement or swelling in the human abdomen)
Abdominal pain lower
Abdominal wall abscess (abdominal wall infection)
Abscess (pus)

50-59:

Anaphylactic reaction (serious allergic reaction)
Back pain
Change of bowel habit
Finger deformity (a deformed position of the finger)
Injection site bruising
Injection site erythema (redness at injection site)
Injection site haemorrhage (bleeding from injection site)
Injection site reaction
Maternal exposure during pregnancy (use of substance during pregnancy)
Myalgia (muscle pain)

60+:

Arthralgia (joint pain)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Gout (uric acid crystals building up in the body)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Inflammatory marker increased
Leukocytosis (increased white blood cells)
Malaise (a feeling of general discomfort or uneasiness)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Sepsis (a severe blood infection that can lead to organ failure and death)
Cholangiocarcinoma (a cancer that forms glands or secretes significant amounts of mucins)

What are the existing conditions these people have? *

Pain: 4 people, 12.50%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 4 people, 12.50%
Muscle Spasms (muscle contraction): 3 people, 9.38%
Back Pain: 3 people, 9.38%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 9.38%
Type 2 Diabetes: 2 people, 6.25%
Joint Pain: 2 people, 6.25%
Insomnia (sleeplessness): 2 people, 6.25%
Hypokalemia (low potassium): 2 people, 6.25%
High Blood Pressure: 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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