Treximet and Calcium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Treximet (naproxen sodium; sumatriptan succinate) and Calcium (calcium). Common drug interactions include nasopharyngitis among females.

The phase IV clinical study analyzes what interactions people have when they take Treximet and Calcium. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Treximet?

Treximet has active ingredients of naproxen sodium; sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 1,904 Treximet users. Check the latest studies of Treximet.

What is Calcium?

Calcium has active ingredients of calcium. It is often used in osteoporosis. eHealthMe is studying from 184,201 Calcium users. Check the latest studies of Calcium.



On Jul, 27, 2026

43 people who take Treximet and Calcium together, and have interactions are studied.

Treximet and Calcium drug interactions.

What are the common drug interactions of Treximet and Calcium, by gender? *:

female:

  1. Nasopharyngitis (inflammation of the nasopharynx)
  2. Nausea (feeling of having an urge to vomit)
  3. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  4. Dyspepsia (indigestion)
  5. Faeces discoloured
  6. Headache (pain in head)
  7. Hypertension (high blood pressure)
  8. Influenza
  9. Cough
  10. Fall

male:

n/a

What are the common drug interactions of Treximet and Calcium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Influenza
  2. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  3. Intervertebral disc protrusion (spinal disc protrusion)
  4. Impaired work ability
  5. Mitochondrial myopathy (the muscle fibres do not function due to damage of mitochondria)
  6. Road traffic accident
  7. Wrist fracture
  8. Tendon rupture (tear of tendon)
  9. Injection site bruising

30-39:

n/a

40-49:

  1. Decreased appetite
  2. Drug ineffective
  3. Eye swelling
  4. Fluid retention (an abnormal accumulation of fluid in the blood)
  5. Leukopenia (less number of white blood cells in blood)
  6. Limb discomfort (discomfort in leg)
  7. Macular oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken)
  8. Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
  9. Nausea (feeling of having an urge to vomit)
  10. Oedema peripheral (superficial swelling)

50-59:

  1. Nasopharyngitis (inflammation of the nasopharynx)
  2. Back pain
  3. Dry eye (lack of adequate tears)
  4. Nausea (feeling of having an urge to vomit)
  5. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  6. Dyspepsia (indigestion)
  7. Faeces discoloured
  8. Hypertension (high blood pressure)
  9. Cough
  10. Fall

60+:

  1. Alopecia (absence of hair from areas of the body)
  2. Myalgia (muscle pain)
  3. Confusional state
  4. Constipation
  5. Coronary artery bypass
  6. Deafness
  7. Depression
  8. Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
  9. Drug effect decreased
  10. Drug ineffective

What are the existing conditions these people have? *

  1. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 20.93%
  2. Immunodeficiency Common Variable: 9 people, 20.93%
  3. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 11.63%
  4. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 9.30%
  5. Hypersensitivity: 4 people, 9.30%
  6. Gait Disturbance: 4 people, 9.30%
  7. Headache (pain in head): 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

Do you take Treximet and Calcium?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Treximet and Calcium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Treximet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Calcium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Treximet and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Calcium and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on naproxen sodium; sumatriptan succinate and calcium (the active ingredients of Treximet and Calcium, respectively), and Treximet and Calcium (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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