Treximet and Modafinil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Treximet (naproxen sodium; sumatriptan succinate) and Modafinil (modafinil). Common drug interactions include drug hypersensitivity among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Treximet and Modafinil. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Treximet?

Treximet has active ingredients of naproxen sodium; sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 1,904 Treximet users. Check the latest studies of Treximet.

What is Modafinil?

Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.

On Jul, 10, 2026

15 people who take Treximet and Modafinil together, and have interactions are studied.

Treximet and Modafinil drug interactions.

What are the common drug interactions of Treximet and Modafinil, by gender? *:

female:

Drug hypersensitivity
Rash erythematous (redness of the skin)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
White blood cell count decreased
Acne (skin problems that cause pimples)
Arthralgia (joint pain)
Bone loss
Drug ineffective
Dyskinesia (abnormality or impairment of voluntary movement)
Fatigue (feeling of tiredness)

male:

Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Treximet and Modafinil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Bone loss
Herpes zoster
Loose tooth
Pruritus (severe itching of the skin)
Throat irritation

40-49:

Memory impairment
Peripheral swelling
Rash erythematous (redness of the skin)
White blood cell count decreased
Acne (skin problems that cause pimples)
Arthralgia (joint pain)
Drug ineffective
Fatigue (feeling of tiredness)
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Skin disorder (skin disease)

50-59:

Dyskinesia (abnormality or impairment of voluntary movement)
Loss of consciousness
Rib fracture

60+:

n/a

What are the existing conditions these people have? *

Pain: 6 people, 40.00%
Itching: 5 people, 33.33%
Nausea (feeling of having an urge to vomit): 5 people, 33.33%
Muscle Spasms (muscle contraction): 5 people, 33.33%
Urticaria (rash of round, red welts on the skin that itch intensely): 5 people, 33.33%
Drowsiness: 4 people, 26.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 26.67%
Herniated Nucleus Pulposus (Slipped Disk): 2 people, 13.33%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 13.33%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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