Treximet and Oxycodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Treximet (naproxen sodium; sumatriptan succinate) and Oxycodone (oxycodone hydrochloride). Common drug interactions include anxiety among females and cerebral infarction among males.

The phase IV clinical study analyzes what interactions people have when they take Treximet and Oxycodone. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Treximet?

Treximet has active ingredients of naproxen sodium; sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 1,904 Treximet users. Check the latest studies of Treximet.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,592 Oxycodone users. Check the latest studies of Oxycodone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 16, 2026

15 people who take Treximet and Oxycodone together, and have interactions are studied.

Treximet and Oxycodone drug interactions.

What are the common drug interactions of Treximet and Oxycodone, by gender? *:

female:

Anxiety
Depression
Renal failure (kidney dysfunction)
Abdominal pain
Asthenia (weakness)
Chronic kidney disease
Erythema (redness of the skin)
Gait disturbance
Hypersensitivity
Hypoaesthesia (reduced sense of touch or sensation)

male:

Cerebral infarction (less blood supply to brain resulting tissue damage)
Asthenia (weakness)
Mood swings (an extreme or rapid change in mood)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Sensory disturbance (sense disturbance)
Aura
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Depression
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)

What are the common drug interactions of Treximet and Oxycodone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Superior sagittal sinus thrombosis (blood clot in the dural venous sinuses, which drain blood from the brain)
Transverse sinus thrombosis (a blood clot in transverse sinus)

30-39:

Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Dysphagia (a condition in which swallowing is difficult or painful)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

40-49:

Cerebral infarction (less blood supply to brain resulting tissue damage)
Erythema (redness of the skin)
Hypersensitivity
Skin discolouration (change of skin colour)
Abdominal pain
Anaemia (lack of blood)
Anion gap increased
Anxiety
Asthenia (weakness)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)

50-59:

Asthenia (weakness)
Depression
Fatigue (feeling of tiredness)
Irritability
Mood swings (an extreme or rapid change in mood)

60+:

Chronic kidney disease
Gait disturbance
Dry eye (lack of adequate tears)
Dry mouth
Emotional disorder
Hypoaesthesia (reduced sense of touch or sensation)
Myalgia (muscle pain)
Nephropathy (damage to or disease of a kidney)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Oedema peripheral (superficial swelling)

What are the existing conditions these people have? *

Headache (pain in head): 3 people, 20.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 20.00%
Neuropathy Peripheral (surface nerve damage): 2 people, 13.33%
Heart Rate Increased: 2 people, 13.33%
Vitamin B12 Deficiency: 2 people, 13.33%
Multiple Allergies (allergy to multiple agents): 2 people, 13.33%
Fungal Infection: 2 people, 13.33%
Muscle Spasms (muscle contraction): 2 people, 13.33%
Nausea (feeling of having an urge to vomit): 2 people, 13.33%
Neuralgia (pain in one or more nerves): 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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