Treximet and Prednisone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Treximet (naproxen sodium; sumatriptan succinate) and Prednisone (prednisone). Common drug interactions include abdominal discomfort among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Treximet and Prednisone. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Treximet?

Treximet has active ingredients of naproxen sodium; sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 1,904 Treximet users. Check the latest studies of Treximet.

What is Prednisone?

Prednisone has active ingredients of prednisone. It is often used in rheumatoid arthritis. eHealthMe is studying from 636,827 Prednisone users. Check the latest studies of Prednisone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

68 people who take Treximet and Prednisone together, and have interactions are studied.

Treximet and Prednisone drug interactions.

What are the common drug interactions of Treximet and Prednisone, by gender? *:

female:

Abdominal discomfort
Dizziness
Foot fracture
Limb injury
Vitreous floaters (spots before the eyes)
Ankle fracture
Blood pressure fluctuation
Constipation
Dyspnoea (difficult or laboured respiration)
Incoherent (talking in a confused and unclear way)

male:

Headache (pain in head)
Muscle spasms (muscle contraction)
Ataxia (loss of full control of bodily movements)
Atelectasis (partial or complete collapse of the lung)
Back pain
Balanitis candida (inflammation of the glands penis by infection with candida albicans)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cerebellar infarction (impaired blood circulation to cerebellum)
Cerebellar syndrome (impaired blood circulation to cerebellum due to lesion in artery)

What are the common drug interactions of Treximet and Prednisone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Gallbladder disorder
Organ failure
Injury
Pain

30-39:

Muscle spasms (muscle contraction)

40-49:

Fall
Fatigue (feeling of tiredness)
Abdominal pain upper
Bone pain
Chondromalacia (anterior knee pain due to irritation of the cartilage on the under surface of the kneecap)
Diarrhoea
Drug ineffective
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)
Fibromyalgia (a long-term condition which causes pain all over the body)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)

50-59:

Nasal septum deviation (deviated nasal septum)
Nausea (feeling of having an urge to vomit)
Neck pain
Nephrolithiasis (calculi in the kidneys)
Neuritis (inflammation of nerve)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Nocardiosis (an infectious disease affecting either the lungs or whole body)
Nuclear magnetic resonance imaging brain
Oropharyngeal pain
Otitis media (inflammation of the middle ear)

60+:

Adverse drug reaction
Chronic kidney disease
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Coronary artery bypass
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Feeling hot
Gastric ulcer (stomach ulcer)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 16 people, 23.53%
Immunodeficiency Common Variable: 7 people, 10.29%
Immunodeficiency: 5 people, 7.35%
Sleep Disorder: 4 people, 5.88%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 5.88%
Headache (pain in head): 4 people, 5.88%
Asthma: 4 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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