Treximet and Rebif drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Treximet (naproxen sodium; sumatriptan succinate) and Rebif (interferon beta-1a). Common drug interactions include chest discomfort among females.

The phase IV clinical study analyzes what interactions people have when they take Treximet and Rebif. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Treximet?

Treximet has active ingredients of naproxen sodium; sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 1,904 Treximet users. Check the latest studies of Treximet.

What is Rebif?

Rebif has active ingredients of interferon beta-1a. It is often used in multiple sclerosis. eHealthMe is studying from 61,126 Rebif users. Check the latest studies of Rebif.

On Jul, 14, 2026

11 people who take Treximet and Rebif together, and have interactions are studied.

What are the common drug interactions of Treximet and Rebif, by gender? *:

female:

Chest discomfort
Chest pain
Haemangioma of liver (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in liver)
Hepatic enzyme increased
Hypothalamo-pituitary disorder (loss of function in an endocrine gland due to failure of the pituitary gland to secrete hormones which stimulate that gland's function)
Menstrual disorder (disease of menstrual cycle)
Menstruation irregular
Somnolence (a state of near-sleep, a strong desire for sleep)
Stress
Drug ineffective

male:

n/a

What are the common drug interactions of Treximet and Rebif, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)

40-49:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Haemangioma of liver (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in liver)
Hepatic enzyme increased
Hypothalamo-pituitary disorder (loss of function in an endocrine gland due to failure of the pituitary gland to secrete hormones which stimulate that gland's function)
Menstrual disorder (disease of menstrual cycle)
Menstruation irregular
Stress
Blood bilirubin increased
Blood follicle stimulating hormone decreased

50-59:

Chest discomfort
Chest pain
Dyspnoea (difficult or laboured respiration)
Hypokalaemia (low potassium)
Hot flush (sudden feelings of heat)
Dizziness
Somnolence (a state of near-sleep, a strong desire for sleep)
Feeling hot

60+:

n/a

What are the existing conditions these people have? *

Menopause (end of monthly cycles in women): 4 people, 36.36%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 36.36%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 36.36%
High Blood Pressure: 4 people, 36.36%
Headache (pain in head): 4 people, 36.36%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 36.36%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 4 people, 36.36%
Menstrual Disorder (disease of menstrual cycle): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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