Treximet and Sumatriptan succinate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Treximet (naproxen sodium; sumatriptan succinate) and Sumatriptan succinate (sumatriptan succinate). Common drug interactions include ulcer haemorrhage among females and benign prostatic hyperplasia among males.

The phase IV clinical study analyzes what interactions people have when they take Treximet and Sumatriptan succinate. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Treximet?

Treximet has active ingredients of naproxen sodium; sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 1,904 Treximet users. Check the latest studies of Treximet.

What is Sumatriptan succinate?

Sumatriptan succinate has active ingredients of sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 9,731 Sumatriptan succinate users. Check the latest studies of Sumatriptan succinate.

On Jul, 14, 2026

54 people who take Treximet and Sumatriptan succinate together, and have interactions are studied.

Treximet and Sumatriptan succinate drug interactions.

What are the common drug interactions of Treximet and Sumatriptan Succinate, by gender? *:

female:

Ulcer haemorrhage (bleeding ulcer)
Urinary tract infection
Drug ineffective
Gallbladder disorder
Pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Fall
Fatigue (feeling of tiredness)
Anxiety
Emotional distress

male:

Benign prostatic hyperplasia (benign enlargement of the prostate)
Hypertension (high blood pressure)
Drug ineffective
Gallbladder disorder
Gastric bypass
Injury
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Pain
Pancreatitis acute (sudden inflammation of pancreas)
Rash

What are the common drug interactions of Treximet and Sumatriptan Succinate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Gallbladder disorder
Fatigue (feeling of tiredness)
Nerve compression
Pain
Tooth disorder (tooth disease)
Anxiety
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Emotional distress

30-39:

Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Gallbladder disorder
Injury
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Pain
Pancreatitis acute (sudden inflammation of pancreas)
Renal failure acute (rapid kidney dysfunction)

40-49:

Drug ineffective
Fall
Limb injury
Upper limb fracture
Ankle fracture
Bone pain
Contusion (a type of hematoma of tissue in which capillaries)
Fibula fracture
Ligament sprain (ligament stretched)
Osteoporosis (bones weak and more likely to break)

50-59:

Hypertension (high blood pressure)
Idiopathic thrombocytopenic purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting)
Oedema peripheral (superficial swelling)
Palpitations (feelings or sensations that your heart is pounding or racing)
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Thrombocytopenia (decrease of platelets in blood)
Obesity (having too much body fat)
Drug ineffective
Dyskinesia (abnormality or impairment of voluntary movement)
Gastric bypass

60+:

Injection site haemorrhage (bleeding from injection site)
Renal failure (kidney dysfunction)
Vomiting
Abdominal discomfort
Adverse drug reaction
Drug effect decreased
Drug ineffective
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 19 people, 35.19%
Headache (pain in head): 5 people, 9.26%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 9.26%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 7.41%
Birth Control: 4 people, 7.41%
Pain: 3 people, 5.56%
Nausea And Vomiting: 3 people, 5.56%
Nausea (feeling of having an urge to vomit): 3 people, 5.56%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 5.56%
Drowsiness: 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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