Treximet and Zoloft drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Treximet (naproxen sodium; sumatriptan succinate) and Zoloft (sertraline hydrochloride). Common drug interactions include pain among females and arterial occlusive disease among males.

The phase IV clinical study analyzes what interactions people have when they take Treximet and Zoloft. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Treximet?

Treximet has active ingredients of naproxen sodium; sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 1,904 Treximet users. Check the latest studies of Treximet.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

On Aug, 06, 2026

27 people who take Treximet and Zoloft together, and have interactions are studied.

What are the common drug interactions of Treximet and Zoloft, by gender? *:

female:

Pain
Suicidal ideation
Hypertension (high blood pressure)
Abdominal discomfort
Abdominal pain
Alopecia (absence of hair from areas of the body)
Back pain
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Chest pain
Cholecystitis chronic (long lasting infection of gallbladder)

male:

Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

What are the common drug interactions of Treximet and Zoloft, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Emotional distress
Injury
Pain
Hypertension (high blood pressure)
Nausea (feeling of having an urge to vomit)
Night sweats (sweating in night)
Adverse drug reaction

40-49:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
Alopecia (absence of hair from areas of the body)
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Headache (pain in head)
Hysterectomy
Muscle spasms (muscle contraction)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Rash pruritic (redness with itching)
Vitamin d decreased

50-59:

Agitation (state of anxiety or nervous excitement)
Anger
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Constipation
Crying
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Feeling hot

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 29.63%
Asthma: 4 people, 14.81%
Pain: 4 people, 14.81%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 11.11%
Stress And Anxiety: 3 people, 11.11%
Tardive Dyskinesia (a disorder that involves involuntary movements): 3 people, 11.11%
Premenstrual Syndrome: 3 people, 11.11%
Restless Leg Syndrome (a powerful urge to move your legs): 3 people, 11.11%
Nausea (feeling of having an urge to vomit): 2 people, 7.41%
Muscle Spasms (muscle contraction): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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