Triglide and Flexeril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Triglide (fenofibrate) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include glucose tolerance impaired among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Triglide and Flexeril. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Triglide?

Triglide has active ingredients of fenofibrate. It is often used in high blood cholesterol. eHealthMe is studying from 287 Triglide users. Check the latest studies of Triglide.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

On Jul, 28, 2026

21 people who take Triglide and Flexeril together, and have interactions are studied.

Triglide and Flexeril drug interactions.

What are the common drug interactions of Triglide and Flexeril, by gender? *:

female:

Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Histrionic personality disorder (long-standing pattern of attention seeking behaviour and extreme emotionality)
Hyperaesthesia
Dyspepsia (indigestion)
Hepatic steatosis (fatty liver disease)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Atelectasis (partial or complete collapse of the lung)
Coronary artery stenosis (narrowing of coronary artery)
Facial pain
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Pulmonary haemorrhage (acute bleeding from the lung)
Urinary tract infection
Chronic kidney disease
Depression
Emotional distress
Pain
Renal failure (kidney dysfunction)
Anaemia (lack of blood)

What are the common drug interactions of Triglide and Flexeril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Hypokalaemia (low potassium)
Urinary tract infection
Chordoma (a brain tumour from the embryo)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)

40-49:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Multi-organ failure (multisystem organ failure)
Activities of daily living impaired
Malaise (a feeling of general discomfort or uneasiness)
Oedema (fluid collection in tissue)
Quality of life decreased
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)

50-59:

Dyspepsia (indigestion)
Hepatic steatosis (fatty liver disease)
Chest discomfort
Costochondritis (chest wall pain)
Depression
Headache (pain in head)
Hypertension (high blood pressure)
Multiple injuries
Neuralgia (pain in one or more nerves)
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)

60+:

n/a

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 9.52%
Pain: 2 people, 9.52%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 9.52%
Hiv Infection: 2 people, 9.52%
Headache (pain in head): 2 people, 9.52%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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