Trikafta and Lamotrigine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trikafta (elexacaftor, ivacaftor, tezacaftor; ivacaftor) and Lamotrigine (lamotrigine). Common drug interactions include sinus disorder among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Trikafta and Lamotrigine. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Trikafta?

Trikafta has active ingredients of elexacaftor, ivacaftor, tezacaftor; ivacaftor. eHealthMe is studying from 11,852 Trikafta users. Check the latest studies of Trikafta.

What is Lamotrigine?

Lamotrigine has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 76,639 Lamotrigine users. Check the latest studies of Lamotrigine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

48 people who take Trikafta and Lamotrigine together, and have interactions are studied.

Trikafta and Lamotrigine drug interactions.

What are the common drug interactions of Trikafta and Lamotrigine, by gender? *:

female:

Sinus disorder (disease of sinus)
Cough
Dizziness
Dry throat
Headache (pain in head)
Insomnia (sleeplessness)
Menstruation irregular
Neck pain
Oropharyngeal pain
Pain

male:

Anxiety
Mood altered (changes in mood)
Emotional disorder
Energy increased
Hepatic enzyme increased
Insomnia (sleeplessness)
Intentional self-injury
Irritability
Joint injury
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)

What are the common drug interactions of Trikafta and Lamotrigine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hospitalisation
Otitis externa (external ear infection)

20-29:

Cough
Dizziness
Dry throat
Headache (pain in head)
Insomnia (sleeplessness)
Menstruation irregular
Neck pain
Oropharyngeal pain
Pain
Sinus disorder (disease of sinus)

30-39:

Hypoaesthesia (reduced sense of touch or sensation)
Loss of consciousness
Arthralgia (joint pain)
Cystic fibrosis (disease of the secretary glands)
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Pneumonia

40-49:

Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Nausea (feeling of having an urge to vomit)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Weight decreased
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Abdominal pain upper
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

50-59:

Infection
Migraine (headache)
Sinus headache (headache caused by sinus infections)
Sinusitis (inflammation of sinus)
Spinal column injury (spinal cord bone injury)
Vomiting

60+:

n/a

What are the existing conditions these people have? *

Cystic Fibrosis (disease of the secretary glands): 46 people, 95.83%

* Approximation only. Some reports may have incomplete information.

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