Trilafon and Lorazepam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trilafon (perphenazine) and Lorazepam (lorazepam). Common drug interactions include diabetes mellitus among females and type 2 diabetes mellitus among males.

The phase IV clinical study analyzes what interactions people have when they take Trilafon and Lorazepam. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Trilafon?

Trilafon has active ingredients of perphenazine. It is often used in bipolar disorder. eHealthMe is studying from 1,448 Trilafon users. Check the latest studies of Trilafon.

What is Lorazepam?

Lorazepam has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,639 Lorazepam users. Check the latest studies of Lorazepam.

On Jul, 26, 2026

68 people who take Trilafon and Lorazepam together, and have interactions are studied.

Trilafon and Lorazepam drug interactions.

What are the common drug interactions of Trilafon and Lorazepam, by gender? *:

female:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Localised exfoliation (a peeling off or loss of epidermis at the site of exposure)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Anaemia (lack of blood)
Cellulitis (infection under the skin)
Pancreatitis (inflammation of pancreas)
Pruritus (severe itching of the skin)
Rash erythematous (redness of the skin)
Rash generalised (rash on most of body parts)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)

male:

Type 2 diabetes mellitus
Back pain
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Tardive dyskinesia (a disorder that involves involuntary movements)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthralgia (joint pain)
Asthma
Blood creatinine increased
Constipation
Delusional disorder, unspecified type

What are the common drug interactions of Trilafon and Lorazepam, by age (0-1 to 60+)? *:

0-1:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Ketoacidosis (high concentrations of ketone bodies in blood)
Tardive dyskinesia (a disorder that involves involuntary movements)

2-9:

n/a

10-19:

n/a

20-29:

Drug abuse
Sopor (sleep)
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
Diabetes mellitus inadequate control
Type 2 diabetes mellitus
Affective disorder (mental disorder)
Agitation (state of anxiety or nervous excitement)
Alcohol abuse
Angina pectoris (chest pain due to ischemia of the heart muscle)
Antisocial personality disorder

30-39:

Aggression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Type 2 diabetes mellitus
Drug abuse
Intentional self-injury
Sopor (sleep)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic hepatitis (long lasting inflammation of liver)

40-49:

Localised exfoliation (a peeling off or loss of epidermis at the site of exposure)
Blood cholesterol increased
Cellulitis (infection under the skin)
Pancreatitis (inflammation of pancreas)
Pruritus (severe itching of the skin)
Rash erythematous (redness of the skin)
Rash generalised (rash on most of body parts)
Skin lesion
Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

50-59:

Personality disorder
Psychotic disorder
Pyrexia (fever)
Renal failure chronic (long lasting kidney dysfunction)
Rhinorrhoea (watery mucus discharge from the nose)
Scar
Schizophreniform disorder (mental disorder is diagnosed when the symptom criteria for schizophrenia are met, but the duration is too short and social and occupational functioning)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sinusitis (inflammation of sinus)
Skin ulcer

60+:

Arthralgia (joint pain)
Hypoaesthesia (reduced sense of touch or sensation)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Fatigue (feeling of tiredness)
Hot flush (sudden feelings of heat)
Hypogonadism (reduction or absence of hormone secretion or other physiological activity of the gonads (testes or ovaries))
Hypokalaemia (low potassium)

What are the existing conditions these people have? *

Depression: 14 people, 20.59%
Narcissistic Personality Disorder (a personality disorder in which the individual is described as being excessively preoccupied with issues of personal): 6 people, 8.82%
Sleep Disorder: 5 people, 7.35%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 7.35%
Pain: 5 people, 7.35%
Schizophrenia, Paranoid Type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect): 4 people, 5.88%
Personality Disorder: 4 people, 5.88%
Insomnia (sleeplessness): 4 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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