Trileptal and Nicotine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trileptal (oxcarbazepine) and Nicotine (nicotine). Common drug interactions include decreased appetite among females and acute coronary syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Trileptal and Nicotine. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Trileptal?

Trileptal has active ingredients of oxcarbazepine. It is often used in bipolar disorder. eHealthMe is studying from 23,558 Trileptal users. Check the latest studies of Trileptal.

What is Nicotine?

Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 20,443 Nicotine users. Check the latest studies of Nicotine.

On Jul, 16, 2026

44 people who take Trileptal and Nicotine together, and have interactions are studied.

Trileptal and Nicotine drug interactions.

What are the common drug interactions of Trileptal and Nicotine, by gender? *:

female:

Decreased appetite
Dependence
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Disturbance in attention
Drug dependence
Drug hypersensitivity
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dry skin
Dysgeusia (disorder of the sense of taste)
Eating disorder

male:

Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dyskinesia (abnormality or impairment of voluntary movement)
Dysphagia (a condition in which swallowing is difficult or painful)
Fungal infection
Gastrointestinal hypomotility (less activity of the intestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Headache (pain in head)
Hyperglycaemia (high blood sugar)

What are the common drug interactions of Trileptal and Nicotine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Apathy
Depression
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dry skin
Educational problem
Infection
Intentional self-injury
Mood swings (an extreme or rapid change in mood)
Rash
Suicidal behaviour

20-29:

Drug toxicity
Polysubstance dependence
Substance abuse
Cardiomegaly (increased size of heart than normal)
Pulmonary oedema (fluid accumulation in the lungs)
Accidental death
Bile duct stone
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cholecystitis chronic (long lasting infection of gallbladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

30-39:

Chest pain
Abdominal pain upper
Biliary colic
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dyspepsia (indigestion)
Hepatic enzyme increased
Palpitations (feelings or sensations that your heart is pounding or racing)
Bronchopleural fistula
Chills (felling of cold)

40-49:

Renal failure (kidney dysfunction)
Renal failure acute (rapid kidney dysfunction)
Septic embolus (a type of embolism that is infected with bacteria)
Social avoidant behaviour (avoiding social connection a personality disorder)
Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)
Suicidal ideation
Suicide attempt
Synovial cyst (cyst of joint filled with synovial fluid)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tachyphrenia (abnormally rapid mental activity)

50-59:

Anger
Dissociation
Hypoaesthesia (reduced sense of touch or sensation)
Pain in extremity
Rash erythematous (redness of the skin)
Rash papular (redness with papule)
Abnormal dreams
Chest pain
Crying
Dyspnoea (difficult or laboured respiration)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 11.36%
Depression: 5 people, 11.36%
High Blood Pressure: 3 people, 6.82%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 3 people, 6.82%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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