Trimethoprim and Propofol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trimethoprim (trimethoprim) and Propofol (propofol). Common drug interactions include neutropenic sepsis among females and platelet count decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Trimethoprim and Propofol. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Trimethoprim?

Trimethoprim has active ingredients of trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 8,213 Trimethoprim users. Check the latest studies of Trimethoprim.

What is Propofol?

Propofol has active ingredients of propofol. It is often used in colonoscopy abnormal. eHealthMe is studying from 38,225 Propofol users. Check the latest studies of Propofol.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 16, 2026

68 people who take Trimethoprim and Propofol together, and have interactions are studied.

Trimethoprim and Propofol drug interactions.

What are the common drug interactions of Trimethoprim and Propofol, by gender? *:

female:

Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Pulmonary embolism (blockage of the main artery of the lung)
Angioedema (rapid swelling of the dermis)
Lip swelling
Oxygen saturation decreased
Pyrexia (fever)
Infusion site pain
Vomiting
Neutropenia (an abnormally low number of neutrophils)

male:

Platelet count decreased
Unresponsive to stimuli
Drug effect prolonged
Procedural site reaction
Blood creatinine increased
Graft rejection (graft failure)
Renal artery thrombosis (blood clot in renal artery)
Renal infarct (kidney damage due to lack of blood supply)
Ureteric obstruction
Cholecystitis acute (rapid infection of gallbladder)

What are the common drug interactions of Trimethoprim and Propofol, by age (0-1 to 60+)? *:

0-1:

Angioedema (rapid swelling of the dermis)
Lip swelling
Oxygen saturation decreased

2-9:

n/a

10-19:

Superinfection bacterial
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Colitis ulcerative (inflammation of colon with ulcer)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Abscess (pus)
Enterobacter infection (infection caused by bacteria of the family enterobacteriaceae)
Hospitalisation
Respiratory tract infection

20-29:

Platelet count decreased
Unresponsive to stimuli
Blood creatinine increased
Graft rejection (graft failure)
Renal artery thrombosis (blood clot in renal artery)
Renal infarct (kidney damage due to lack of blood supply)
Ureteric obstruction
Abdominal pain
Procedural site reaction

30-39:

Propofol infusion syndrome
Pulmonary embolism (blockage of the main artery of the lung)
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Thrombocytopenia (decrease of platelets in blood)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)

40-49:

Anal abscess
Anxiety
Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Genital abscess (build up of pus in genital)
Necrosis (the death of body tissue)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Perirectal abscess
Renal failure (kidney dysfunction)
Tooth abscess (pus formation in tooth)

50-59:

Weight fluctuation
Weight increased
Anaemia (lack of blood)
Arterial haemorrhage
Death
Delirium (wild excitement)
Dizziness
Fibromyalgia (a long-term condition which causes pain all over the body)
Fluid imbalance (imbalance of fluid in body in intake and fluid lost)
Gastrointestinal disorder (functional problems of gastrointestinal tract)

60+:

Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Blood fibrinogen increased
Haematuria (presence of blood in urine)
Red blood cell count decreased
Vein pain
Cholecystitis acute (rapid infection of gallbladder)
Arthralgia (joint pain)
Blood alkaline phosphatase nos increased
Blood bilirubin increased

What are the existing conditions these people have? *

Fever: 24 people, 35.29%
Wound: 22 people, 32.35%
Skin Ulcer: 22 people, 32.35%
Oedema Peripheral (superficial swelling): 22 people, 32.35%
Joint Pain: 22 people, 32.35%
Dry Skin: 22 people, 32.35%
Cellulitis (infection under the skin): 22 people, 32.35%
Breast Cancer Metastatic: 22 people, 32.35%
Abdominal Hernia Obstructive (abdominal hernia causing a blockage): 22 people, 32.35%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 10 people, 14.71%

* Approximation only. Some reports may have incomplete information.

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