Trimethoprim and Seroquel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trimethoprim (trimethoprim) and Seroquel (quetiapine fumarate). Common drug interactions include nausea among females and diabetes mellitus among males.

The phase IV clinical study analyzes what interactions people have when they take Trimethoprim and Seroquel. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Trimethoprim?

Trimethoprim has active ingredients of trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 8,213 Trimethoprim users. Check the latest studies of Trimethoprim.

What is Seroquel?

Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. eHealthMe is studying from 120,285 Seroquel users. Check the latest studies of Seroquel.



On Jul, 12, 2026

36 people who take Trimethoprim and Seroquel together, and have interactions are studied.

Trimethoprim and Seroquel drug interactions.

What are the common drug interactions of Trimethoprim and Seroquel, by gender? *:

female:

  1. Nausea (feeling of having an urge to vomit)
  2. Weight decreased
  3. Delirium (wild excitement)
  4. Diabetic complication
  5. Apathy
  6. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  7. Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)
  8. Bacterial infection
  9. Blood culture positive
  10. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

male:

  1. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  2. Back pain
  3. Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
  4. Chest discomfort
  5. Chest pain
  6. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  7. Constipation
  8. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  9. Cough
  10. Diabetic complication

What are the common drug interactions of Trimethoprim and Seroquel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  2. Cardiac arrest
  3. Emotional distress
  4. Hypoxic-ischaemic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)
  5. Memory impairment
  6. Migraine (headache)
  7. Scar

30-39:

  1. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  2. Diabetic retinopathy (damage to the retina caused by complications of diabetes)
  3. Ataxia (loss of full control of bodily movements)
  4. Fall
  5. Tremor (trembling or shaking movements in one or more parts of your body)
  6. Completed suicide (act of taking one's own life)
  7. Drug toxicity
  8. Multiple drug overdose intentional

40-49:

  1. Pharyngitis (inflammation of the pharynx, causing a sore throat)
  2. Pneumonia
  3. Vomiting
  4. Diabetic complication
  5. Apathy
  6. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  7. Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)
  8. Bacterial infection
  9. Blood culture positive
  10. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

50-59:

  1. Delirium (wild excitement)
  2. Chronic kidney disease
  3. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

60+:

  1. Dysphagia (a condition in which swallowing is difficult or painful)
  2. Dysarthria (speech disorder)
  3. Anxiety
  4. Ataxia (loss of full control of bodily movements)
  5. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  6. Back pain
  7. Cardiac failure congestive
  8. Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
  9. Chest discomfort
  10. Chest pain

What are the existing conditions these people have? *

  1. Depression: 8 people, 22.22%
  2. Stress And Anxiety: 4 people, 11.11%
  3. Dementia (madness): 3 people, 8.33%
  4. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 8.33%
  5. Psychotic Disorder: 3 people, 8.33%
  6. Pain: 3 people, 8.33%
  7. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 8.33%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 8.33%
  9. Insomnia (sleeplessness): 3 people, 8.33%
  10. Hallucinations (sensations that appear real but are created by your mind): 3 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Trimethoprim and Seroquel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Trimethoprim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Seroquel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Trimethoprim and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Seroquel and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on trimethoprim and quetiapine fumarate (the active ingredients of Trimethoprim and Seroquel, respectively), and Trimethoprim and Seroquel (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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