Trintellix and Celexa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trintellix (vortioxetine hydrobromide) and Celexa (citalopram hydrobromide). Common drug interactions include joint swelling among females and agitation among males.

The phase IV clinical study analyzes what interactions people have when they take Trintellix and Celexa. It is created by eHealthMe based on reports of 82 people who take the same drugs from the FDA, and is updated regularly.

What is Trintellix?

Trintellix has active ingredients of vortioxetine hydrobromide. It is often used in depression. eHealthMe is studying from 13,067 Trintellix users. Check the latest studies of Trintellix.

What is Celexa?

Celexa has active ingredients of citalopram hydrobromide. It is often used in depression. eHealthMe is studying from 56,390 Celexa users. Check the latest studies of Celexa.

On Jul, 13, 2026

82 people who take Trintellix and Celexa together, and have interactions are studied.

Trintellix and Celexa drug interactions.

What are the common drug interactions of Trintellix and Celexa, by gender? *:

female:

Joint swelling
Lethargy (tiredness)
Meningitis viral (viral inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Peripheral swelling
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Restlessness (not able to rest)
Skin exfoliation (removal of the oldest dead skin cells)
Nausea (feeling of having an urge to vomit)
Headache (pain in head)

male:

Agitation (state of anxiety or nervous excitement)
Bruxism (habitual grinding of the teeth, typically during sleep)
Lethargy (tiredness)
Nervousness
Feeling jittery
Restlessness (not able to rest)
Vomiting
Aggression
Asthma
Mood swings (an extreme or rapid change in mood)

What are the common drug interactions of Trintellix and Celexa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug ineffective
Pruritus (severe itching of the skin)

30-39:

Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Flushing (the warm, red condition of human skin)
Nausea (feeling of having an urge to vomit)
Swelling face
Urticaria (rash of round, red welts on the skin that itch intensely)
Vomiting
Gait disturbance
Impaired healing
Osteonecrosis (death of bone)

40-49:

Mania (a state of abnormally elevated or irritable mood)
Suicide attempt
Loss of consciousness
Asthma
Cardiac disorder
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Headache (pain in head)
Hypersensitivity
Infusion related reaction
Lower limb fracture

50-59:

Drug ineffective
Fatigue (feeling of tiredness)
Agitation (state of anxiety or nervous excitement)
Bruxism (habitual grinding of the teeth, typically during sleep)
Disturbance in attention
Dizziness
Lethargy (tiredness)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)
Abdominal discomfort

60+:

Nausea (feeling of having an urge to vomit)
Arthralgia (joint pain)
Vomiting
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Asthenia (weakness)
Balance disorder
Blood pressure fluctuation
Headache (pain in head)
Heart rate irregular
Irritability

What are the existing conditions these people have? *

Stress And Anxiety: 17 people, 20.73%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 14.63%
Migraine (headache): 10 people, 12.20%
Pain: 8 people, 9.76%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 7 people, 8.54%
High Blood Cholesterol: 6 people, 7.32%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 7.32%

* Approximation only. Some reports may have incomplete information.

Do you take Trintellix and Celexa?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously